S100A4

(redirected from fibroblast-specific protein-1)

S100A4

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which have 2 EF-hand calcium-binding motifs. S100 proteins are localised in the cytoplasm and/or nucleus of a wide range of cells; they are involved in regulating cell cycle progression and differentiation and other intracellular activities. The S100A4-encoded protein is thought to play a role in motility, invasion and tubulin polymerisation.
 
Molecular pathology
S100A4 rearrangements have been implicated in tumour metastasis.
References in periodicals archive ?
The samples were analyzed by immunohistochemistry of CD29, CD44, CD90, and CD45 and observed by light microscopy.[14] Fibroblasts were also cultured on glass coverslips in six-well plates for 7 days and then analyzed by immunohistochemistry of fibroblast-specific protein-1 (FSP-1).
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