Expression of fibroblast growth factor
receptor 1 (FGFR1) measured by RT-qPCR (A and B) and immunohistochemical (IHC) staining (C and D; magnification 100 x , 50[micro]pm) in 74 pairs of tumor (T) tissues and adjacent non-tumorous (N) tissues from gastric cancer patients.
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Abbreviations FGF21: Fibroblast growth factor
21 MyoG: Myogenin CDKs: Cyclin-dependent kinases MAPK: Mitogen-activated protein kinase PI3K: Phosphoinositide 3-kinase UCP1: Uncoupling protein 1 PGC1[alpha]: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha.
It included 7-d-old male rats that were randomised into four groups: fibroblast growth factor
2-20, fibroblast growth factor
2-40, control and sham.
We selected six fibroblast growth factor
genes and two fibroblast growth factor
receptor genes from which we designed eight primer pairs for qPCR validation (Supplementary Table S1).
Fibroblast growth factor
21 (FGF21) is a typical member of the fibroblast growth factor
Because the VEGF was being neutralised by Avastin, the cancer cells instead produced more FGF (fibroblast growth factor
), another protein involved in the creation of blood vessels.
--Canada patent 2,459,957--This patent contains claims related to the feeder-free culture of pluripotent stem cells wherein the stem cells are grown on an extracellular matrix and stimulated to grow with a fibroblast growth factor
. In addition, the patent contains additional claims such as to genetically-modified pluripotent stem cells grown on such feeder-free conditions.