fibrinoid necrosis


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Related to fibrinoid necrosis: Coagulative necrosis

fi·brin·oid ne·cro·sis

necrosis in which the necrotic tissue has some staining reactions resembling fibrin and becomes deeply eosinophilic, homogenous, and refractile.

fibrinoid necrosis

'Smudgy' eosinophilic fibrin-like deposits, of degenerated collagen or ground substance, in arterial walls of Pts with malignant HTN and periarteritis nodosa; FN may also occur in the Arthus reaction, acute rheumatic fever, SBE, near peptic ulcers, rheumatoid arthritis, immune complex disease, HBV, malignancy, complement C2 deficiency, Henoch-Schönlein purpura, SLE and other collagen vascular diseases. See Fibrosis, Necrosis.
References in periodicals archive ?
We found no evidence of rheumatoid nodules, dural inflammation, or fibrinoid necrosis.
Other nonspecific features include intimal proliferation, duplication and/or fragmentation of the internal elastic lamina, a sparse perivascular inflammatory infiltrate, and fibrinoid necrosis of the intima.
Fibrin deposition was found in areas of fibrinoid necrosis within the glomeruli (Figure 2, B) and in the interstitium.
Multiple vessels demonstrated fibrinoid necrosis of the vascular wall and microthrombi due to extensive neutrophilic vasculitis (Fig.
Histological analysis of the small bowel segment revealed the presence of a small vessel vasculitis with typical fibrinoid necrosis suggestive of HSP (figure 3).
Anthrax vasculitis was identified as a key pathologic lesion in the Sverdlovsk casesand wascharacterized by fibrinoid necrosis of the vessel wall with mild neurotrophic and moderate macrophage infiltration.
In grade 4 hypertensive retinopathy, the systemic diastolic blood pressure is usually at least 130 to 140 mmHg, With both grades 3 and 4 hypertensive retinopathy, the increased blood pressure can damage the blood vessel wall, leading to fibrinoid necrosis (the presence of fibrin thromhi within the vascular luminal.
The epithelium is nearly always ulcerated, showing fibrinoid necrosis at the surface.
With cerebral amyloid angiopathy, there is progressive amyloid deposition restricted to small- to medium-sized vessels of the brain that leads to fibrinoid necrosis and vascular frailty, and there is often associated diffuse multifocal white matter disease, and symptomatic lobar hemorrhage.
Multifocal areas of edema, fibrinoid necrosis, and lymphocytic infiltration also were observed (Figure).
The parameters of renal lesion, hypercellularity, infiltration of polymorphonuclear leukocyte (PMN), fibrinoid necrosis, focal and segmental proliferation and interstitial infiltration, were reversed.
In this case the clinical and histopathological findings did not fulfill the criteria of eosinophilic vasculitis in which there should be damage to the elastic fibers or fibrinoid necrosis concomitant to eosinophilic cellular infiltration.