Reticulocytosis in peripheral blood can also be attributed to the deposition of fibrinoid material
and foam cells around the arteriole in preeclampsia.
The predominant lesion, found in decreasing severity in kidney, brain, lymph nodes, spleen, liver, intestine, and lung, was fibrinoid necrosis of vessels with marked segmental to diffuse vasculitis, disruption of subendothelial tunica intima, and expansion with thick bands of deeply eosinophilic hyaline to fibrinoid material
admixed with karyorrhectic debris and degenerate neutrophils (Figure 1).
The distinct invasiveness of the trophoblast and the intimacy of the junctional zone are associated with a characteristic fibrinoid material
, probably of trophoblastic origin (Kirby et al.
A histopathological examination revealed a cystic lesion in the paratesticular region that contained many hemosiderin-laden macrophages and an area of cystic degeneration containing broken, digested fibrinoid material
surrounded by longitudinal muscles (Fig.
Early PHAT can resemble HFLT such that it was postulated that HFLT may represent the precursor lesion of classical PHAT, (28) and PHAT is again a circumscribed lesion with hemosiderin pigment within tumor cells and focal myxoid change, although mature PHAT looks distinct from HFLT, comprising clusters of angiectatic thin-walled vessels with hyaline and fibrinoid material
within their walls, along with spindle cells with large hyperchromatic nuclei and prominent intranuclear inclusions.
Accumulation of focal fibrinoid material
and fibroelastic proliferation were detected in small arteries and arterioles of these patients .
They often contain well-circumscribed areas of eosinophilic fibrinoid material
with a substantial degree of karyorrhexis.
It was also noted that, when necrosis was overt, eosinophilic fibrinoid material
The diagnosis is best established with a histologic examination--or cytologically if the aspirate contains sufficient cells in addition to blood and fibrinoid material
Abundant fibrinoid material
is often identified on the side adjacent to the implant of the fibrous capsule.
Blood vessels are sometime occluded by fibrinoid material
and surrounded by foam cells.
Small nerve units were also caught up in this scarifying process, which failed to show necrobiotic foci, fibrinoid material
, or nuclear dust.