Many other histopathological changes were also noticed in the animals of group C such as glomerular sclerosis, mesangial widening, vascular congestion, perivascular inflammation, swelling of the nuclei of the tubular epithelaial cells, fibrinoid change
in the afferent arterioles, lobulation of glomeruli and atrophy of glomeruli, however these changes were not observed in a significant number of animals that could be elaborated (Fig.
The diagnosis of acute TCMR was based on the following criteria: IA, cases with significant interstitial infiltration (>25% of parenchyma affected, i2 or i3), and foci of moderate tubulitis (t2); IB, cases with significant interstitial infiltration (>25% of parenchyma affected, i2 or i3), and foci of severe tubulitis (t3); IIA, cases with mild-to-moderate intimal arteritis (v1); IIB, cases with severe intimal arteritis comprising >25% of the luminal area (v2); III, cases with "transmural" arteritis and/or arterial fibrinoid change
and necrosis of medial smooth muscle cells with accompanying lymphocytic inflammation (v3) .
72 h follow-up (range) Banff 97 score (a) 0.70 [+ or -] 0.46 (0-1) Giant cell score (b) 0.08 [+ or -] 0.27 (0-1) 4 w follow-up (range) Banff 97 score (a) 0.34 [+ or -] 0.47 (0-1) Giant cell score (b) 0.30 [+ or -] 0.46 (0-1) 12 w follow-up (range) Banff 97 score (a) 0.28 [+ or -] 0.45 (0-1) Giant cell score (b) 0.38 [+ or -] 0.49 (0-1) (a) Banff 97 score: 0 = no arteritis; 1 = mild-to-moderate intimal arteritis; 2 = severe intimal arteritis with at least 25% luminal area lost; 3 = transmural arteritis and-or arterial fibrinoid change
and medial smooth muscle necrosis with lymphocytic infiltrate in vessel.
H, This area shows chronic vasculitis with fibrinoid change
in the vessels (hematoxylin-eosin, original magnifications X200 and X400 [inset]).
The histopathology report indicated scarring dermis and mixed cell infiltrate, leucocytoclastic vasculitis, fibrinoid changes
, and some diffusely spread histiocytes.