FGG

(redirected from fibrinogen gamma chain)

FGG

A gene on chromosome 4q28 that encodes the gamma component of fibrinogen, a circulation glycoprotein which is comprised of three pairs of nonidentical polypeptide chains. After vascular injury, fibrinogen is cleaved by thrombin to form fibrin, which is the most abundant component of blood clots. Various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, have vasoconstrictor and chemotactic activities, and are mitogenic for various cell types.

Molecular pathology
Defects in FGG are linked to dysfibrinogenaemia, hypofibrinogenaemia and thrombophilia.
References in periodicals archive ?
In Table 4, complement C3, complement C4, complement component C6, complement factor H precursor, properdin precursor, complement component C8 gamma chain, complement component C8 beta chain, adiponectin, galectins, fibronectin type III domain-containing protein 1, fibrinogen beta chain, fibrinogen gamma chain, kininogen1, apolipoprotein H, and glutathione-S-transferase were included.
We identified and quantified in the 2-DE gels the following proteins: alpha-1 antitrypsin isotypes 1 to 6, fetoprotein, three fibrinogen gamma chain isotypes, three vitamin D binding protein isotypes, five alpha-1 antichymotrypsin isotypes, six haptoglobin isotypes, six serotransferrin isotypes, tropomyosin (Table 2).
These proteins were identified by MALDI as: 7x-1-antitrypsin (AAT), Fibrinogen gamma chain (FGG), Apolipoprotein A-1 (Apo A-1), Immunoglobulin gamma heavy chain (IGG), Transthyretin (TTR), Alpha 2HS glycoprotein, Troponin I, Serpin, Transforming protein ra1B and an unknown protein labeled as Q5JYW7.