fibrinogen

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Related to fibrinogen deficiency: cryoprecipitate, prothrombin deficiency

fibrinogen

 [fi-brin´o-jen]
a high-molecular-weight protein in the blood plasma that by the action of thrombin is converted into fibrin; called also factor i. In the clotting mechanism, fibrin threads form a meshwork for the basis of a blood clot. Most of the fibrinogen in the circulating blood is formed in the liver. Normal quantities of fibrinogen in the plasma vary from 100 to 700 mg per 100 ml of plasma.

Commercial preparations of human fibrinogen are used to restore blood fibrinogen levels to normal after extensive surgery, or to treat diseases and hemorrhagic conditions that are complicated by afibrinogenemia.
fibrinogen degradation products fragments of fibrinogen or fibrin degraded by plasmin, which are found in the serum and urine of patients with disseminated intravascular coagulation (DIC) and in the urine of patients who have had renal transplants.

fi·brin·o·gen

(fī-brin'ō-jen),
A globulin of the blood plasma converted into fibrin by the action of thrombin in the presence of ionized calcium to produce coagulation of the blood; the only coagulable protein in the blood plasma of vertebrates; it is absent in afibrinogenemia and is defective in dysfibrinogenemia.

fibrinogen

(fī-brĭn′ə-jən)
n.
A protein in the blood plasma that is essential for the coagulation of blood and is converted to fibrin by the action of thrombin in the presence of ionized calcium.

fi′bri·nog′e·nous (fī′brə-nŏj′ə-nəs) adj.

fibrinogen

Coagulation factor I, factor I Hematology A soluble 340 kD plasma glycoprotein required for normal platelet function and wound healing; it is converted into fibrin in the common pathway of coagulation, and provides physical scaffolding for permanent hemostatic plugs, which is orchestrated under thrombin's baton; fibrinogen is an 'acute phase reactant,' which may be markedly ↑ in various types of nonspecific stimuli–eg, inflammation, hemostatic stress, pregnancy, autoimmune diseases; it is ↑ in hyperfibrinogenemia; ↓ in afibrinogenemia

fi·brin·o·gen

(fī-brin'ō-jen)
A globulin of the blood plasma that is converted into fibrin by the action of thrombin in the presence of ionized calcium to produce coagulation of the blood; the only coagulable protein in the blood plasma of vertebrates; absent in afibrinogenemia and defective in dysfibrinogenemia.

fibrinogen

A protein in the blood that is converted to FIBRIN by the action of THROMBIN in the presence of ionized calcium, thereby bringing about coagulation of blood.

fibrinogen

or

fibrin

a large, soluble protein found in BLOOD PLASMA that is formed in the liver and is converted to insoluble fibrin by the enzyme thrombin during the process of BLOOD CLOTTING.

Fibrinogen

A type of blood protein called a globulin that interacts with thrombin to form fibrin.
Mentioned in: Prothrombin Time

fi·brin·o·gen

(fī-brin'ō-jen)
A globulin of blood plasma converted into fibrin by action of thrombin in presence of ionized calcium to coagulate blood; the only coagulable protein in the blood plasma of vertebrates; it is absent in afibrinogenemia and defective in dysfibrinogenemia.

Patient discussion about fibrinogen

Q. What Are the Risk Factors for Developing Stroke? My father had a stroke recently, at the age of 73. What are the risk factors for developing this?

A. Primary risk factors include:

1) smoking
2) excessive alcohol intake
3) uncontrolled high blood pressure
4) high cholesterol
5) overweight/unhealthy diet
6) illegal drugs/abuse of Rx drugs
7) known or unknown heart problems
8) diabetes
9) known or unknown vascular brain defects - aneurysm, etc.
10)family history of stroke

Q. Regarding risk-factor assessment? Hello, I am……….., I heard ACSM has recently issued a new edition of its exercise guidelines. Were any changes made regarding risk-factor assessment?

A. Are you fitness professional? I understand that you are very much interested in food guidelines. It can be difficult to keep up with the latest guidelines and standards. This is particularly true this year, which has seen new USDA Food Guidelines in January, a revised Food Pyramid in May and, most recently, the release of the 7th edition of ACSM’s Guidelines for Exercise Testing and Prescription. The good news is that the ACSM risk factors have been minimally revised. For your reference, here is a summary of what has and has not changed for the 2006 edition.

Q. Is obesity a risk factor for Dementia?

A. The answer is YES. In fact, many of the risk factors for heart disease, such as high blood pressure, blood glucose levels, insulin resistance, and overweight, are also risk factors for dementia, in addition to genetic predisposition for the disease.

More discussions about fibrinogen
References in periodicals archive ?
This report provides comprehensive information on the therapeutic development for Fibrinogen Deficiency (Factor I Deficiency), complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases.
* The report provides a snapshot of the global therapeutic landscape of Fibrinogen Deficiency (Factor I Deficiency)
* The report reviews key players involved in the therapeutics development for Fibrinogen Deficiency (Factor I Deficiency) and enlists all their major and minor projects
[ClickPress, Mon Feb 10 2014] Global Markets Direct's, 'Fibrinogen Deficiency (Factor I Deficiency) - Pipeline Review, H2 2013', provides an overview of the indication's therapeutic pipeline.
* Coverage of the Fibrinogen Deficiency (Factor I Deficiency) pipeline on the basis of route of administration and molecule type.
* Identify and understand important and diverse types of therapeutics under development for Fibrinogen Deficiency (Factor I Deficiency).

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