FGA

(redirected from fibrinogen alpha chain)

FGA

A gene on chromosome 4q28 that encodes the alpha chain of a fibrinogen, a heterotrimeric glycoprotein which is cleaved by thrombin to form fibrin, the most abundant component of blood clot.

Molecular pathology
FGA  mutations are linked to afibrinogenaemia (which is universally fatal in infancy), hypofibrinogenaemia, dysfibrinogenaemia and renal amyloidosis.
Mentioned in ?
References in periodicals archive ?
2 Coagulation factor XI (c) Complement C1r (c) Actin (c) Complement C3 (c) Complement C4B (c0 Talin-1 (c) Apolipoprotein B-100 (c) Complement C5 (c) Ceruloplasmin (c) Alpha-1 antichymotrypsin (c) Inter alpha trypsin inhibitor (c) Kallistratin (c) Corticosteroid-binding globulin (c) Serum paraoxonase (c) Fibronectin (c) Plasmonogen like protein A (c) Complement C2 (c) Fibrinogen alpha chain (c) Extracellular matrix protein-1 (c) Collagen alpha 3 (c) Protein disulphide isomerase A3 (c) LFQ LC-MS/MS Fold change (a) T = 24 h vs Protein description T = 30 min Fibrinogen gamma chain 1.
miR-451 deficiency is associated with altered endometrial fibrinogen alpha chain expression and reduced endometriotic implant establishment in an experimental mouse model.

Full browser ?