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a high-molecular-weight protein in the blood plasma that by the action of thrombin is converted into fibrin; called also factor i. In the clotting mechanism, fibrin threads form a meshwork for the basis of a blood clot. Most of the fibrinogen in the circulating blood is formed in the liver. Normal quantities of fibrinogen in the plasma vary from 100 to 700 mg per 100 ml of plasma.

Commercial preparations of human fibrinogen are used to restore blood fibrinogen levels to normal after extensive surgery, or to treat diseases and hemorrhagic conditions that are complicated by afibrinogenemia.
fibrinogen degradation products fragments of fibrinogen or fibrin degraded by plasmin, which are found in the serum and urine of patients with disseminated intravascular coagulation (DIC) and in the urine of patients who have had renal transplants.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


A globulin of the blood plasma converted into fibrin by the action of thrombin in the presence of ionized calcium to produce coagulation of the blood; the only coagulable protein in the blood plasma of vertebrates; it is absent in afibrinogenemia and is defective in dysfibrinogenemia.
Farlex Partner Medical Dictionary © Farlex 2012


A protein in the blood plasma that is essential for the coagulation of blood and is converted to fibrin by the action of thrombin in the presence of ionized calcium.

fi′bri·nog′e·nous (fī′brə-nŏj′ə-nəs) adj.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


Coagulation factor I, factor I Hematology A soluble 340 kD plasma glycoprotein required for normal platelet function and wound healing; it is converted into fibrin in the common pathway of coagulation, and provides physical scaffolding for permanent hemostatic plugs, which is orchestrated under thrombin's baton; fibrinogen is an 'acute phase reactant,' which may be markedly ↑ in various types of nonspecific stimuli–eg, inflammation, hemostatic stress, pregnancy, autoimmune diseases; it is ↑ in hyperfibrinogenemia; ↓ in afibrinogenemia
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.


A globulin of the blood plasma that is converted into fibrin by the action of thrombin in the presence of ionized calcium to produce coagulation of the blood; the only coagulable protein in the blood plasma of vertebrates; absent in afibrinogenemia and defective in dysfibrinogenemia.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012


A protein in the blood that is converted to FIBRIN by the action of THROMBIN in the presence of ionized calcium, thereby bringing about coagulation of blood.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005




a large, soluble protein found in BLOOD PLASMA that is formed in the liver and is converted to insoluble fibrin by the enzyme thrombin during the process of BLOOD CLOTTING.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005


A type of blood protein called a globulin that interacts with thrombin to form fibrin.
Mentioned in: Prothrombin Time
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.


A globulin of blood plasma converted into fibrin by action of thrombin in presence of ionized calcium to coagulate blood; the only coagulable protein in the blood plasma of vertebrates; it is absent in afibrinogenemia and defective in dysfibrinogenemia.
Medical Dictionary for the Dental Professions © Farlex 2012

Patient discussion about fibrinogen

Q. What Are the Risk Factors for Developing Stroke? My father had a stroke recently, at the age of 73. What are the risk factors for developing this?

A. Primary risk factors include:

1) smoking
2) excessive alcohol intake
3) uncontrolled high blood pressure
4) high cholesterol
5) overweight/unhealthy diet
6) illegal drugs/abuse of Rx drugs
7) known or unknown heart problems
8) diabetes
9) known or unknown vascular brain defects - aneurysm, etc.
10)family history of stroke

Q. Regarding risk-factor assessment? Hello, I am……….., I heard ACSM has recently issued a new edition of its exercise guidelines. Were any changes made regarding risk-factor assessment?

A. Are you fitness professional? I understand that you are very much interested in food guidelines. It can be difficult to keep up with the latest guidelines and standards. This is particularly true this year, which has seen new USDA Food Guidelines in January, a revised Food Pyramid in May and, most recently, the release of the 7th edition of ACSM’s Guidelines for Exercise Testing and Prescription. The good news is that the ACSM risk factors have been minimally revised. For your reference, here is a summary of what has and has not changed for the 2006 edition.

Q. Is obesity a risk factor for Dementia?

A. The answer is YES. In fact, many of the risk factors for heart disease, such as high blood pressure, blood glucose levels, insulin resistance, and overweight, are also risk factors for dementia, in addition to genetic predisposition for the disease.

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References in periodicals archive ?
When they receive information from fibrinogen, they go into action and accumulate in the remaining part of the liver to help restore it, increasing the chances of a fully functional liver and successful recovery.
Fibrinogen levels were measured by a coagulometric method (BCS XP, Siemens Healthcare Diagnostics, Marburg, Germany).
The AIS group had significantly higher levels of TG, LDL, D-dimer, NT-pro BNP and fibrinogen as well as IMT than those of the control group, but the HDL level of the AIS group was significantly lower (P<0.05) (Table-I).
Therefore, sealing and biocompatibility properties must be optimal to obtain successful results (1).In this in vitro study, we evaluated genotoxicity, hemolysis, and fibrinogen quantification of EB and AWMTA cements.
Fibrinogen was elevated in subjects with diabetes mellitus (4.3 [+ or -] 4 versus 3.2 [+ or -] 2 mg/ml, p = 0.027) (Table 1).
In order to assess the correlation of fibrinogen concentrations and the influence of PAD, the study population was divided into quarters according to the fibrinogen concentration (Q1: [less than or equal to] 3.01 g/L; Q2: 3.02-3.65g/L; Q3: 3.66-4.55g/L; and Q4: [greater than or equal to] 4.56 g/L).
The following tests of haemostasis are done only once: Platelet count and peripheral smear, PT (Prothrombin time), aPTT (activated Partial Thromboplastin Time), Fibrinogen and D-dimer.
Upon admission, serum levels of CRP, fibrinogen, N-terminal of the pro-hormone brain natriuretic peptide (NT-proBNP) and WBC count were measured.
In the presented work, we used fluorescently labeled fibrinogen to obtain a relationship between fiber light intensity, I, which is proportional to the number of monomers in a fiber cross-section, and fiber diameter, D.
Fibrinogen, a major coagulation protein associated with inflammation, seems to be an important biomarker for cardiovascular risk [20], and its levels have been found to be directly related to apnea-hypopnea index (AHI) and arousal index (AI) and inversely related to mean and lowest oxygen saturation during sleep [21].

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