fibrin glue

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Related to fibrin glue: Fibrin sealant

fibrin sealant

mixed fibrinogen and thrombin applied to sites to curtail hemorrhage or as a delivery mechanism to provide regional long-term growth factor or other drug delivery.
Synonym(s): fibrin glue

fibrin glue

Fibrin sealant Surgery A liquid commercial product composed of purified fibrinogen and thrombin used to seal operative wounds, by partially re-enacting the final stage of the coagulation cascade, in which fibrinogen is converted to fibrin in the presence of thrombin, factor XIII, fibronectin and calcium ions; FS are mixed at the 'table,' and used to seal complex surgical wounds–eg, anorectal fistulas


an insoluble protein that is essential to clotting of blood, formed from fibrinogen by action of thrombin.

fibrin-fibrinogen degradation products (FDPs)
the breakdown products of fibrin and fibrinogen, resulting from activation of the fibrinolytic system, they inhibit fibrin formation and platelet adherence. Elevated levels are found in the blood and urine in association with disseminated intravascular coagulation and detection is a test for that condition.
fibrin-fibrinogen split products
see fibrin-fibrinogen degradation products (above).
fibrin foam
a clot promoting surgical material for application to oozing surfaces. Strips of fine white sponge to be soaked in thrombin solution before application.
fibrin glue
a mixture of bovine thrombin and concentrated fibrinogen. It may be used topically or by injection in management of hemostasis.
fibrin plate method
a method of measuring fibrinolytic activity by incubating a fibrin clot with test serum in a Petri dish.
soluble fibrin monomers
a stage in the clot formation process of producing insoluble fibrin monomers.
fibrin stabilizing factor
see fibrin stabilizing factor.
References in periodicals archive ?
As the internal opening margin exhibited fibrosis and scar formation, we injected 3% saline around the internal orifice to induce tissue inflammation and adhesion; subsequently, 2 ml of fibrin glue was injected from external side to internal opening of the fistula to form a plug through the fistula.
Amniotic membrane transplantation and fibrin glue in the management of corneal ulcers and perforations: A review of 33 cases.
We packed the middle ear space with muscle, fat, and fibrin glue, both sealing the cochleostomy and obliterating the middle ear space.
The iCMBAs had two and a half to eight times better adhesion in wet tissue conditions than fibrin glue.
The bioahesives, called iCMBAs, adhere well in wet environments, have controlled degradability, improved biocompatibility and lower manufacturing costs, putting them a step above current products such as fibrin glue and cyanoacrylate adhesives.
The strategies employed in these techniques include plugging the fistula with fibrin glue or tissue adhesives, (3) plugging it after de-epithelisation of the fistula, (5,6) or obliteration of the fistula using cauterisation or laser therapy.
En este caso, los autores usaron unicamente fibrin glue posicionado superficialmente, sin diatermia o algun tipo de tecnica de desepitelizacion previa con buenos resultados, a los cuatro anos de postoperatorio.
In all the 10 patients fibrin glue was used as an adhesive material.
In 9 interventional procedures (dental extraction: 2, ophthalmic operation: 2, circumscision: 5), hemostasis was provided by single or combined use of thrombocyte transfusion, tranexamic acid, recombinant activated factor VII (rVIIa) and fibrin glue.
Topical treatment such as fibrin glue has been previously described with limited success.
Cultured human keratinocytes as a single cell suspension in fibrin glue combined with preserved dermal grafts enhanced reconstitution in athymic mice full-thickness wounds.