fibrin-fibrinogen degradation products

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Related to fibrin degradation products: fibrinogen, Fibrin Split Products, D dimer

fibrin-fibrinogen degradation products

Fibrin 'splits' Hematology Polypeptide fragments of fibrin degradation, which are generated by unchecked 1º fibrinolysis. See Disseminated intravascular coagulation.
Fibrin degradation products
Intravascular lesions Associated with DIC, DVT, and PTE–ie, pathological fibrinolysis
Extravascular conditions eg, hematomas, neoplasia, sepsis, allograft rejection, glomerular disease, severe liver disease and obstetric complications, eg abruptio placentae, eclampsia, retained dead fetus

fibrin-fibrinogen degradation products

A group of soluble protein fragments produced by the proteolytic action of plasmin on fibrin or fibrinogen. These products impair the hemostatic process and are a major cause of hemorrhage in intravascular coagulation and fibrinogenolysis.
References in periodicals archive ?
It has been shown that SFC in plasma from patients with DIC exists as complexes with a variety of fibrinogen derivatives, including intact fibrinogen as well as early and late fibrin degradation products. Accordingly, if the relative concentrations of the various fibrinogen derivatives present in the complex vary depending on the disease stage, the specificities of the MoAbs used for SFC immunoassays may affect the quantitative results for SFC in plasma.
According to the ISTH Subcommittee on DIC, major laboratory criteria for the diagnosis of overt DIC include platelet count, prothrombin time, fibrinogen level, and a marker of the presence of fibrin, which can be ascertained by one of the following assays: soluble fibrin monomer, fibrin degradation products, and/or D-dimer.
The relationship of soluble fibrin and cross-linked fibrin degradation products to the clinical course of myocardial infarction.
Fibrinogen equivalent units express the concentration of fibrin degradation products in terms of the gravimetrically determined mass of fibrinogen from which they were derived.