These include increased inflammatory mediators and loss of keratocytes, abnormal enzyme function and loss of collagen, anomalous keratocyte function and altered fibrillogenesis
, altered proteoglycan production, reduced tensile strength, collagen slippage in cone, and cone formation by biomechanically coupled curvature transfer.
Alongside controlling collagen fibrillogenesis
and collagen organization, studies have revealed the importance of SLRPs in regulating proliferation and migration of SMCs, which are predominant in the media of muscular arteries.
Sonnenberg, "The fibronectin-binding integrins [[alpha].sub.5][[beta].sub.1] and [[alpha].sub.V][[beta].sub.3] differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis
," Journal of Cell Biology, vol.
Type I collagen provides mechanical strength to tissues while type III contributes to elasticity and regulates collagen fibril diameter during fibrillogenesis
. With the onset of menopause, estrogen and progesterone hormones are progressively reduced which are protective against tissue deterioration and important to maintain the tissue integrity.
Canty-Laird, "Collagen fibrillogenesis
: fibronectin, integrins, and minor collagens as organizers and nucleators," Current Opinion in Cell Biology, vol.
Electrospun In vivo (i) Significantly higher collagen I (rabbit) fibrillogenesis
after PDS nanofiber/ treatment.
Forlenza, "Alzheimer's disease," in Protein Aggregation and Fibrillogenesis
in Cerebral and Systemic Amyloid Disease, J.
FMOD was reported to play important roles in modulating extracellular matrix (ECM) organization  and collagen fibrillogenesis
[15, 16] and also is reported as a regulator of cell reprogramming [17, 18].
Podlisny et al., "Certain inhibitors of synthetic amyloid [beta]-peptide (A[beta]) fibrillogenesis
block oligomerization of natural A[beta] and thereby rescue longterm potentiation," The Journal of Neuroscience, vol.
It is also known for influencing fibril formation for collagens type I and II, accelerating fibrillogenesis
and binding to aggrecan, mediating the organization of cartilage matrix for its load bearing function.
The involvement of members of this family in collagen fibrillogenesis
as well as cellular growth, differentiation, and migration reveal their importance in shaping the extracellular matrix (13).
MMP-9 knockout mice displayed impaired cutaneous wound healing accompanied by defects in keratinocyte migration and collagen fibrillogenesis
; however, a lack of MMP-9 enhances the rate of wound closure in injured corneas .