Polymorphous low-grade adenocarcinoma versus pleomorphic adenoma of minor salivary glands: resolution of a diagnostic dilemma by immunohistochemical analysis with glial fibrillary
acidic protein and CD57 immunolocalization in cell block preparations is a useful adjunct in the diagnosis of pleomorphic adenoma.
The pituicytoma, or infundibuloma, is a rare tumor of the sellar region that displays a spindle cell morphology, fascicular arrangement of tumor cells, and variable glial fibrillary
acidic protein (GFAP) immunoreactivity.
2, S-100 protein, glial fibrillary
acidic protein, immunoreactive calcitonin, immunoreactive parathyroid hormone, and epithelial membrane antigen.
The cuboidal cells lining the pseudopapillae were strongly positive for glial fibrillary
acidic protein [GFAP, [Figure 1]e and vimentin but were negative for neuron-specific enolase (NSE) and neuronal nuclear antigen [NeuN, [Figure 1]f, suggesting glial differentiation.
In addition to large histiocytoid or ganglion-like cells with inclusion-like nucleoli, there are spindle cells with fibrillary
cytoplasm (Figure 7), large epithelioid cells with abundant eosinophilic cytoplasm (Figure 8), degenerated cells with smudged chromatin (Figure 9), neoplastic cells filled with mucoid vacuoles, so-called pseudolipoblasts found within myxoid areas (Figure 10), and large histiocytoid cells with emperipolesis, usually containing intracytoplasmic neutrophils (Figure 11).
acid protein (GFAP), ubiquitin c-terminal hydrolase LI (UCH-L1), as well as other proteins, including microtubule-associated protein tau, amyloid beta peptide (A[beta]342), and neurofilament light (NfL), have been proposed as promising diagnostic and prognostic biomarkers in TBI.
It is important to note that the cells are reactive with desmin (figure 2), myoglobin, myogenin, Myo-Dl, and smooth muscle actin; they occasionally express focal S-100 protein and glial fibrillary
An immunofluorescence study with antibodies to the glial fibrillary
acidic (GFA) protein.
To confirm that the neoplasm derives from Schwann cells, the following markers were evaluated: neurofilament (table 1 and figure 2A), glial fibrillary
acidic protein (table 1 and figure 2B), synaptophysin (table 1 and figure 2C), Leu-7 (table 1 and figure 2D), protein S-100 (table 1 and figure 2E), dimentin (table 1 and figure 2F).
Pseudoexfoliation syndrome (PES) is a disorder of the extracellular matrix characterized by the progressive accumulation of abnormal fibrillary
material in many ocular tissues.
Immunohistochemical analysis of neurofilament (Figure 1C), neuron-specific enolase (NSE) (Figure 1D), glial fibrillary
acidic protein (GFAP) (1D inset) and S100 (Figure 1E) showed a positive reaction in the cytoplasm of ganglion cells, extending to their cellular processes.