The risk factors of pulmonary hypertension are limited systemic sclerosis with anti-centromere antibody, severe Raynaud's phenomenon, disease start at late age and presence of antibodies to U1RNP, U3RNP (Fibrillarin
) and B23.
RNA2 encodes two nonstructural proteins p2 and pc2; p2 is a viral RNA-silencing suppressor and is involved in systemic viral movement by interacting with fibrillarin [7, 8], and pc2 shares many characteristics common to the glycoproteins [9, 10].
Fibrillarin, an important nucleolus protein, was reported to interact with viral proteins and regulate virus replication, movement, and so on.
Levels and Nuclear Distribution Pattern of Coilin, Fibrillarin, and SC35 in Mouse Brain and Pluripotent or Differentiated mESCs.
In parallel with coilin, we analyzed fibrillarin levels in the mouse brains because individual CBs colocalize with fibrillarin in many cell types (Figures 4(c), 5(a), and 5(b)).
1997), and modification of the nucleolar antigen fibrillarin
from a 34-kDa non-disulfide-bonded form to a 32-kDa disulfide-bonded form.
Our results are in agreement with a similar observation reported in the literature that high intensity fibrillarin
spots reveal the dense fibrillar component .
In order to identify "disease biomarkers" useful for the clinical and therapeutic management of autoimmune disorders, in the present study we assessed an extended panel of nuclear, nucleolar, and cytoplasmic autoantigens, including those associated with SSc (Topoisomerase-I, Cenp-A/B, RNAP III, Th/To, Fibrillarin
, PDGFR) as well as dermatomyositis (Mi-2, Jo-1, PL-7, PL-12, EJ, OJ, SRP) or other overlapping syndromes (PM-Scl 75 e PM Scl 100, Ku, Ro-52, NOR 90)  facing the determination of the regulatory T cell levels in patients with different clinical forms of SSc and in subjects presenting with a UCTD.
Therefore, our combined data suggest that the major responses in asbestos-exposed individuals include antibody development to targets such as chromatin components (i.e., histone) or nucleolar components (fibrillarin
, DNA topoisomerase I), which give the homogeneous and nucleolar patterns, and several ENAs that give the speckled pattern.
Urinary mercury levels in patients with autoantibodies to U3-RNP (fibrillarin
1994), which have been related to the presence of antibodies to fibrillarin
(Pollard et al.
Analysis of the autoantibody response to fibrillarin
in human disease and murine models of autoimmunity.