fibric acid

fibric acid

 [fi´brik]
any of a group of compounds structurally related to clofibrate used to reduce plasma levels of triglycerides and cholesterol.
References in periodicals archive ?
The large antihyperlipidemic class of drugs can be subdivided into bile acid sequestrants, HMG-CoA reductase inhibitors, fibric acid derivatives, ezetimibe, and niacin.
FIBRATES gemfibrozil Impressive triglyceride-lowering and HDL cholesterol-boosting effects make fibric acid derivatives especially attractive in diabetic patients.
Results of studies of the fibric acid derivatives are mixed.
Drugs used in hyperlipidaemia are 3-hydroxy-3methyl glutaryl coenzyme A reductase (HMG-CoA reductase) inhibitors, niacin, fibric acid derivatives and bile acid binding resins.2 The statins are the most effective and best tolerated agents for treating dyslipidaemias.
Action on the former is associated with lipid reduction, as with the fibric acid derivatives, while PPAR-gamma agonists such as rosiglitazone and pioglitazone lower glucose levels by reducing insulin resistance.
While cholesterol-modifying agents include 4 different classes--statins, fibric acid derivatives, bile acid resins, "and nicotinic acid--studies cited in this paper predominantly involved statins "and fibric acids, ha systematic reviews of both primary and secondary prevention trials, statins were the most effective agents for both cholesterol lowering and cardiovascular risk reduction.
Secondary goals include weight reduction and increased physical activity in persons with the metabolic syndrome and consideration of niacin or fibric acid for patients with low HDL and/or high triglycerides.
Muscle symptoms also can be caused by fibric acid derivatives, nicotinic acid, other types of medications, or illicit drugs.
This is achievable using niacin and/or fibric acid derivatives.
FIBRATES gemfibrozil Impressive triglyceride-lowering and HDL cholesterol--boosting effects make fibric acid derivatives especially attractive in diabetic patients.
The hypolipidemic drugs which were prescribed for different disease conditions belonged mainly to single agents (statins, fibric acid derivatives) or to fixed dose combinations (statins with fenofibrate).