fibric acid

[fi´brik]

any of a group of compounds structurally related to clofibrate used to reduce plasma levels of triglycerides and cholesterol.

References in periodicals archive ?

The large antihyperlipidemic class of drugs can be subdivided into bile acid sequestrants, HMG-CoA reductase inhibitors, fibric acid derivatives, ezetimibe, and niacin.

Antihyperlipidemic agents

FIBRATES gemfibrozil Impressive triglyceride-lowering and HDL cholesterol-boosting effects make fibric acid derivatives especially attractive in diabetic patients.

Drug update: lipid modification for secondary prevention of coronary events

Results of studies of the fibric acid derivatives are mixed.

What levels of cholesterol should be treated for primary prevention? (Clinical Inquiries)

Drugs used in hyperlipidaemia are 3-hydroxy-3methyl glutaryl coenzyme A reductase (HMG-CoA reductase) inhibitors, niacin, fibric acid derivatives and bile acid binding resins.2 The statins are the most effective and best tolerated agents for treating dyslipidaemias.

Comparison of simvastatin with Eugenia Jambolana fruit pulp in their effects on Alanine Transferase, Aspartate Aminotransferase and Creatinine Phosphokinase levels of hyperlipidaemic rats

Action on the former is associated with lipid reduction, as with the fibric acid derivatives, while PPAR-gamma agonists such as rosiglitazone and pioglitazone lower glucose levels by reducing insulin resistance.

Tesaglitazar improves glucose, lipids in type 2 diabetics

While cholesterol-modifying agents include 4 different classes--statins, fibric acid derivatives, bile acid resins, "and nicotinic acid--studies cited in this paper predominantly involved statins "and fibric acids, ha systematic reviews of both primary and secondary prevention trials, statins were the most effective agents for both cholesterol lowering and cardiovascular risk reduction.

Treatment of hyperlipidemia. (Applied Evidence)

Periodic liver function monitoring is also recommended for treatment with the fibric acid derivative gemfibrozil.

What laboratory monitoring is appropriate to detect adverse drug reactions in patients on cholesterol-lowering agents? (Clinical Inquiries: From The Family Practice Inquiries Network)

Secondary goals include weight reduction and increased physical activity in persons with the metabolic syndrome and consideration of niacin or fibric acid for patients with low HDL and/or high triglycerides.

Stable angina update

Muscle symptoms also can be caused by fibric acid derivatives, nicotinic acid, other types of medications, or illicit drugs.

Statin-induced myopathy is underrecognized: premature fatigue, fixed weakness. (Cardiovascular Medicine)

This is achievable using niacin and/or fibric acid derivatives.

Treating Low-HDL, High-Triglyceride Patients

FIBRATES gemfibrozil Impressive triglyceride-lowering and HDL cholesterol--boosting effects make fibric acid derivatives especially attractive in diabetic patients.

Drug update: lipid modification for secondary prevention of coronary events. (RX)

The hypolipidemic drugs which were prescribed for different disease conditions belonged mainly to single agents (statins, fibric acid derivatives) or to fixed dose combinations (statins with fenofibrate).

Study of prescribing patterns of hypolipidemic agents in a tertiary care teaching hospital in North India

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