fexofenadine hydrochloride


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fexofenadine hydrochloride

Allegra, Allegra ODT, Telfast (UK)

Pharmacologic class: Peripherally selective piperidine, selective histamine1-receptor antagonist

Therapeutic class: Antihistamine (nonsedating type), second-generation

Pregnancy risk category C

Action

Blocks effects of histamine at peripheral histamine1-receptor sites, decreasing allergy signs and symptoms

Availability

Capsules: 60 mg

Oral suspension: 30 mg/5 ml (6 mg/ml)

Tablets: 30 mg, 60 mg, 180 mg

Tablets (orally disintegrating): 30 mg

Indications and dosages

Seasonal allergic rhinitis; chronic idiopathic urticaria

Adults and children age 12 and older: 60 mg P.O. b.i.d. or 180 mg once daily (conventional tablets)

Children ages 6 to 11: 30 mg P.O. b.i.d. (conventional tablets or ODT tablets)

Seasonal allergic rhinitis

Children ages 2 to 11: 30 mg P.O. b.i.d. (oral suspension and ODT)

Chronic idiopathic urticaria

Children ages 6 months to less than 2 years: 15 mg P.O. b.i.d.(oral suspension and ODT)

Dosage adjustment

• Renal impairment

Contraindications

• Hypersensitivity to drug, terfenadine, or their components

Precautions

Use cautiously in:

• renal impairment

• concurrent ketoconazole or erythromycin therapy

• elderly patients

• pregnant or breastfeeding patients.

Administration

• Give capsules and conventional tablets with water; don't give with apple, orange, or grapefruit juice.

• Don't remove orally disintegrating tablets from original blister package until time of administration.

• Administer orally disintegrating tablets on an empty stomach; allow tablets to disintegrate on the tongue and then have patient swallow tablets with or without water.

• Don't break or use partial orally disintegrating tablets

• Know that orally disintegrating tablets contain phenylalanine.

• Don't give antacids within 2 hours of fexofenadine.

Adverse reactions

CNS: drowsiness, fatigue, headache

EENT: otitis media

GI: nausea, dyspepsia

Metabolic: dysmenorrhea

Respiratory: upper respiratory tract infection

Other: viral infection

Interactions

Drug-drug. Antacids containing aluminum and magnesium: decreased absorption and efficacy of fexofenadine

Drug-diagnostic tests. Skin allergy tests: false-negative results

Drug-food. Apple, orange, and grapefruit juice: decreased absorption and efficacy of fexofenadine

Patient monitoring

• Monitor renal function.

• Watch for signs and symptoms of viral infection.

Patient teaching

• Instruct patient to take conventional tablets with water, and not with apple, orange, or grapefruit juice.

• Instruct patient not to remove orally disintegrating tablets from original blister package until time of administration.

• Instruct patient to take orally disintegrating tablets on an empty stomach at least 1 hour before or 2 hours after a meal, to allow tablet to disintegrate on the tongue, and then to swallow with or without water. Advise patient not to chew tablets.

• Tell patient not to break or use partial orally disintegrating tablets.

• Tell patient to stop taking drug 4 days before diagnostic skin tests, to avoid interference with test results.

• Advise patient to report signs or symptoms of viral infection, especially upper respiratory tract infection.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• Advise female patient to inform prescriber if she is pregnant or breastfeeding.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, tests, and foods mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved
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References in periodicals archive ?
In this regard, a study was conducted devoted to the study of the antiallergic action of the combined nasal spray containing fexofenadine hydrochloride and ammonium glycyrrhizinate.
Fexofenadine hydrochloride in the treatment of allergic disease: a review.
Rajendra, "Simultaneous quantification of pseudoephedrine hydrochloride and fexofenadine hydrochloride in tablets by liquid chromatography," Jordan Journal of Pharmaceutical Sciences, vol.
Shah, "Stability indicating RP-HPLC method development and validation for pseudoephedrine hydrochloride and fexofenadine hydrochloride in tablet dosage form," International Journal of Pharmaceutical Sciences and Research, vol.
Reddy's Laboratories, an integrated global pharmaceutical company, has introduced its over-the-counter Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride Extended Release Tablets 60 mg/120 mg, a bioequivalent generic version of Allegra-D 12 Hour Allergy & Congestion, in the United States, it was reported on Friday.
The company's Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride Extended Release Tablets 60 mg/120 mg are offered in 20 count blister packs.
The applicability of the proposed methods for the assay of fexofenadine hydrochloride in formulations was examined by analyzing various formulations and the results tabulated in Table 4 were compared to the official HPLC method for fexofenadine hydrochloride [31] by means of t- and F-values at 95% confidence level.
The developed kinetic spectrophotometric method for the determination of fexofenadine hydrochloride in bulk and pharmaceutical formulations was sensitive, accurate, and precise.
Reddy's Laboratories (NYSE:RDY) disclosed on Thursday the introduction of its US FDA approved over-the-counter (OTC) Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride Extended Release Tablets 60 mg / 120 mg in a 20 count blister in the US market.
Other products launched in 2005 include fexofenadine hydrochloride tablets, AB rated and bioequivalent to Aventis' Allegra; azithromycin tablets, AB rated and bioequivalent to Pfizer's Zithromax; oxycodone hydrochloride extended-release tablets, AB rated and bioequivalent to Purdue Pharma's OxyContin; paroxetine tablets USP, AB rated and bioequivalent to GlaxoSmithKiine PLC's Paxil; and ribavirin tablets, AB rated and bioequivalent to Roche's Copegus.
The antihistamine (fexofenadine hydrochloride) had annual domestic sales in 2005 of around $1.4 billion.
have entered into an agreement for the launch of fexofenadine hydrochloride tablets (30-, 60- and 180-mg tablets), the generic version of Aventis Pharmaceuticals' Allegra.