Preliminary studies had shown that the positive control of 10 mg/kg CP was suitable for studying transplacental genotoxicity, as it shows a significant increase in MN frequency but not significant fetotoxicity
In general, because of fetotoxicity
of ACE inhibitors and angiotensin II receptor antagonist drugs, these agents should be avoided in pregnancy and lactation.
Therefore, the copaiba oil delivered in the vaginal cream, in the concentration employed, did not determine the appearance of fetotoxicity
Placental to fetal transfer of mercury and fetotoxicity
and death of offspring are reported in guinea pigs at doses of 4.
Animal investigations have confirmed the embryotoxicity and fetotoxicity
of DMSA, and it has been suggested that this toxicity might be mediated through changes in copper and zinc metabolism (47-50).
Numerous studies have shown Se supplementation counteracts the negative impacts of exposure to Hg, particularly in regard to neurotoxicity, fetotoxicity
, and developmental toxicity.
vascular lesions, chloracne, teratogenicity, fetotoxicity
, impaired reproductive performance, endometriosis and delayed death.
or teratogenicity was observed when metronidazole was administered orally to pregnant mice at six times the recommended human vaginal dose (based on mg/m2); however, in a single small study where the drug was administered intraperitoneally, some intrauterine deaths were observed.
Threshold for carbon monoxide induced fetotoxicity
However, these adverse developmental effects have only been demonstrated at high doses in conjunction with severe fetotoxicity
Although the impact of manganese exposures on fetuses and neonates has not been studied extensively in humans, a number of laboratory studies have found that prenatal and postnatal exposure to manganese is associated with embryotoxicity, fetotoxicity
, and decreased postnatal growth in rats and mice.