fetoprotein


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fetoprotein

(fē′tə-prō′tēn, -tē-ĭn)
n.
Any of several antigens normally present in a fetus and occurring abnormally in adults as a result of certain cancers or diseases of the liver.

fe·to·pro·tein

, alpha (α)-fetoprotein (AFP) , gamma (γ)-fetoprotein , beta (β)-fetoprotein (fē'tō-prō'tēn, al'fă, gam'ă, bātă)
Fetal proteins found in small amounts in adults in the following forms: 1) AFP increases in maternal blood during pregnancy; when detected by amniocentesis, is an important indicator of neural tube defects (e.g., spina bifida); used as a tumor marker in adults with hepatocellular carcinoma; 2) beta (β)-fetoprotein, although a fetal liver protein, has been detected in adult patients with liver disease; and 3) gamma (γ)-fetoprotein occurs in association with various neoplasms.
See also: fetoglobulins

fetoprotein

(fe?to-pro'ten)
An antigen present in the human fetus and in certain pathological conditions in adults. The amniotic fluid level can be used to evaluate fetal development. Elevated serum levels are found in adults with certain kinds of liver diseases.
See: alpha-fetoprotein
References in periodicals archive ?
Ultrasound and serum alpha fetoprotein levels are currently the mainstay of screening.
Exclusion of the existence of embryonic tumors requires determination of serum levels of alpha fetoprotein and beta chorionic gonadotropin.
Williams, "Prognostic value of serum alpha fetoprotein in fulminant hepatic failure including patients treated by charcoal haemoperfusion," Gut, vol.
Alpha fetoprotein, beta chorionic gonodatropine and lactate dehydrogenase are used as testicular tumor markers (10).
A fetoprotein is a sensitive marker for malignant germ cell tumors like yolk sac tumor and malignant teratoma.
The main aim of the present study was to know the role of the alpha fetoprotein in diagnosis of the premature rupture of the membranes.
The first case was of a 20-year-old woman at 19 weeks' gestation who presented with maternal serum alpha fetoprotein (AFP) elevated by 4.4 multiples of the median (MOM).
An English study found that measuring human chorionic gonadotrophin was a much better test for detecting the presence of Down's syndrome than methods currently used -- measuring unconjugated estriol and alpha fetoprotein. These older tests have a detection rate of approximately 30 percent, while screening for human chorionic gonadotrophin would detect over 60 percent of effected pregnancies.
Immunohistochemical staining for anti-EpCAM (Mouse, B302 - 323 / A3, Abcam, 1:200) and anti-alpha1 fetoprotein (Rabbit, EPR9309, Abcam, 1:50) was performed according to manufacturer instructions.
The study also emphasizes on the importance of clinical presentation, median age at presentation and evaluation of raised titres of serum alpha fetoprotein levels in hepatoblastoma.