We here report on a female patient with angiotensin II receptor antagonist-related fetopathy
. Our patient is the first child of a 35-year-old mother.
Causes of Death in Cases of Unexpected Intrauterine Fetal Demise (IUFD) by Center (Ctr) (a) Cause of Death in Ctr 1 Ctr 2 Ctr 3 Unexpected IUFD Disseminated fetal infectionb 2 1 1 Diabetic fetopathy
1 Hydrops (immune and nonimmune) 1 2 Significant umbilical cord 6 4 2 abnormality/cord accident Severe placental pathology (c) 10 7 6 Massive fetomaternal 2 hemorrhage Severe maternal disease/ 1 uterine anomaly Undetermined 1 Total 23 14 10 Cause of Death in Ctr 4 Ctr 5 Total, Unexpected IUFD No.
Alcohol embryo and fetopathy
. Neuropathology of 3 children and 3 fetuses.
Angiotensin-converting enzyme inhibitor fetopathy
. Journal of the American Society of Nephrology, 3, 1575-1582.
Again, none of the babies had any evidence of ACE inhibitor fetopathy
Angiotensin-converting enzyme inhibitors (ACEIs) are effective antihypertensive drugs, but use of ACEIs during the second and third trimesters of pregnancy has been associated with a pattern of defects known as ACEI fetopathy
. The predominant feature of the fetopathy
is renal tubular dysplasia.
It is this fetal hyperinsulinemia that leads to most of the fetal problems, collectively known as diabetic fetopathy
, seen in diabetic pregnancy (26).