Landon served as the principal investigator of a large national, randomized controlled trial that showed a reduction in the risk of fetal overgrowth
, shoulder dystocia, cesarean delivery, and hypertensive disorders in women who were treated for mild gestational diabetes (N Engl J Med.
Placental transport and metabolism in fetal overgrowth
, a workshop report.
Of much concern is the increased risk of fetal overgrowth
and long-term health consequences for children of obese mothers.
Placental mesenchymal dysplasia associated with fetal overgrowth
and mosaic deletion of the maternal copy of 11p15.
Yes This randomized, controlled trial of 958 women who had mild gestational diabetes (GDM) found that dietary intervention, self-monitoring of blood glucose, and (when necessary) insulin therapy reduced the risk of fetal overgrowth
, shoulder dystocia, cesarean delivery, and hypertensive disorders, compared with customary obstetric care.
However, they were taller than control and asymmetric LGA newborns, providing indirect evidence of a genetic cause in symmetric fetal overgrowth
Jirtle's team is focusing on the finding's implications for cancer, but it might explain why people are less susceptible than some animals to fetal overgrowth
Human embryos appear relatively immune to such laboratory-induced alterations, as evidenced by the fact that fetal overgrowth
rarely occurs with vitro fertilization or other types of assisted reproduction.
Neonates of women who would be added to the diagnosis of gestational diabetes mellitus by criteria established by the International Association of the Diabetes and Pregnancy Study Groups had greater measures of fetal overgrowth
, compared with controls.
However, despite of strict glycemic control in modern clinical management of the pregnant woman with significant hyperglycemia, fetal overgrowth
remains an important clinical problem.
Treating mild gestational diabetes lowered the risks of fetal overgrowth
, shoulder dystocia, cesarean delivery, and gestational hypertension, as well as decreasing maternal weight gain, according to a report in almost 1,000 women.
Loss of the imprinted Igf2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth
and perinatal lethality.