These alterations could be related to an oxygenation deficiency in the fetus and changes in the transplacental transport of nutrients, increasing their availability to the fetus and thus causing fetal overgrowth
(Prieto Sanchez, 2013; Bastos Aires & dos Santos).
Lois Donovan: Yes, pregnant women should be screened for GDM because identification of women with GDM allows treatment that has been shown consistently in randomized controlled trials and metaanalysis to improve pregnancy outcomes; specifically, reduced rates of shoulder dystocia, fetal overgrowth
, and gestational hypertension.
Increased placental nutrient transport in a novel mouse model of maternal obesity with fetal overgrowth
. Obesity (Silver Spring) 2015;23:1663-1670.
Landon served as the principal investigator of a large national, randomized controlled trial that showed a reduction in the risk of fetal overgrowth
, shoulder dystocia, cesarean delivery, and hypertensive disorders in women who were treated for mild gestational diabetes (N Engl J Med.
Placental transport and metabolism in fetal overgrowth
, a workshop report.
Of much concern is the increased risk of fetal overgrowth
and long-term health consequences for children of obese mothers.
Placental mesenchymal dysplasia associated with fetal overgrowth
and mosaic deletion of the maternal copy of 11p15.5.
Yes This randomized, controlled trial of 958 women who had mild gestational diabetes (GDM) found that dietary intervention, self-monitoring of blood glucose, and (when necessary) insulin therapy reduced the risk of fetal overgrowth
, shoulder dystocia, cesarean delivery, and hypertensive disorders, compared with customary obstetric care.
Jirtle's team is focusing on the finding's implications for cancer, but it might explain why people are less susceptible than some animals to fetal overgrowth
. "This marked species difference in IGF2R gene imprinting indicates that humans may be easier to clone than nonprimates," Jirtle says, who adds that he's not advocating such attempts.
Human embryos appear relatively immune to such laboratory-induced alterations, as evidenced by the fact that fetal overgrowth
rarely occurs with vitro fertilization or other types of assisted reproduction.
Neonates of women who would be added to the diagnosis of gestational diabetes mellitus by criteria established by the International Association of the Diabetes and Pregnancy Study Groups had greater measures of fetal overgrowth
, compared with controls.
Persson stated that babies of GDM mothers on insulin treatment and on diet control are similar in the weight.23 But a recent study by Wong has proven the fact that the babies of insulin treated GDM were heavier than diet control GDM mothers, so more GDM mothers on insulin treatment delivered through cesarean section due to fetal overgrowth
and heavy term babies24 and is coinciding with our findings.