fetal hemoglobin


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he·mo·glo·bin F

[MIM*142200]
normal fetal Hb (Hb F) of molecular formula α2Aγ2F, which is the major Hb component during intrauterine life, decreasing rapidly during infancy to reach a concentration of less than 0.5% in normal children and adults; the concentration of Hb F is increased in some hemoglobinopathies and in some cases of hypoplastic anemia, pernicious anemia, and leukemia; Hb F has a weaker affinity for 2,3-bisphosphoglycerate than does Hb A. More than 50 mutant variants of the γ chain have been reported.
Synonym(s): fetal hemoglobin

fetal hemoglobin

n.
The predominant form of hemoglobin in fetuses and newborn infants, present in small amounts in adults but often elevated in adults with certain forms of anemia and other disorders.

fetal hemoglobin

Hemoglobin F An immature Hb composed of 2 α and 2 γ chains that usually disappears in the neonatal period. See Hereditary persistence of fetal hemoglobin.
References in periodicals archive ?
Total Male Female Age BMI (%) (%) Years Kg/[m.sup.2] 72 35 37 35 [+ or -] 24.2 [+ or -] 16.9 4.19 (49) (51) Total SBP DBP Pain eGFR mmHg mmHg crisis ml/min 72 118 [+ or -] 76 [+ or -] 2 127 [+ or -] 13 24 40 Total Hb HbF% HU g/dL (%) 72 10.5 [+ or -] 17.6 [+ or -] 70 1.6 7.1 (97) BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; eGFR: estimated glomerular filtration rate; Hb: hemoglobin; HbF: fetal hemoglobin; HU: hydroxyurea.
The value of fetal hemoglobin level in the management of Nigerian sickle cell anemia patients.
Gravely et al., "The chemical heterogeneity of the fetal hemoglobin in normal newborn infants and in adults," Molecular and Cellular Biochemistry, vol.
Evidence also showed that osteonecrosis was significantly associated with taller height in patients, a longer diagnosis time, previous trauma and presence of pain in the hip, as well as lower Charnley score mean value, lower fetal hemoglobin rate, and higher hemoglobin value.
Rucknagel, "The effect of fetal hemoglobin on the survival characteristics of sickle cells," Blood, vol.
Reactivation of fetal hemoglobin in patients with beta-thalassemia.
The potential of reactivating fetal hemoglobin via manipulating the gene transcription of [beta]- or [gamma]-globin has been gained much attention recently.
The researchers used a specialized tool, a genetically engineered zinc finger (ZF) protein, which they custom-designed to latch onto a specific DNA site carrying the code for fetal hemoglobin.
Human fetal hemoglobin is present in vivo as both an acetylated [F.sub.1] ([alpha][alpha][gamma][[gamma].sup.acetyl]) form by the presence of acetyl groups at the N[H.sub.2] termini of they chains and a nonacetylated [F.sub.0] ([alpha][alpha][gamma][gamma]) form.
Since fetal hemoglobin is more apt to ferric state compared to adult hemoglobin (Hb A2), newborn infants have a greater tendency to methemoglobinemia.
Although cordocentesis and amniocentesis can give an estimate of fetal hemoglobin status, both of these methods are invasive in nature.
More recently, the generation of RBCs containing fetal hemoglobin driven by hypoxia exposure has been shown (14).