Two issued patents cover the proprietary synthetic process used to manufacture fenfluramine
and dexfenfluramine, phentermine was not withdrawn from the market at that time.
The drug was generally well-tolerated in the study, with adverse events consistent with those observed previously and the known safety profile of fenfluramine
Risk of valvular heart disease associated with use of fenfluramine
. BMC Cardiovasc Disord.
With the exception of fenfluramine
, all drugs approved before 1996 were structurally related to amphetamine, although they differed in their effects on enhancing the turnover of norepinephrine and dopamine, thus differing in their abuse potential.
Lelord, "Urinary dopamine metabolites as indicators of the responsiveness to fenfluramine
treatment in children with autistic behavior," Journal of Autism and Developmental Disorders, vol.
Cardiovascular and autonomic effects of fenfluramine
A greater prolactin response to fenfluramine
was associated with treatment resistance in one study .
Drugs used for treatment include thyroid hormones, fenfluramine
. Currently phentermine, topiramate, serotonin agonists, cannibinoid receptors antagonists are the known anti obesity preparations.
Other serotonergic medications previously used for weight loss, such as fenfluramine
, stimulated the serotonin 2b receptor, which may have contributed to an increased risk of cardiac valve disease.
The year after chairing the panel, Pi-Sunyer was identified in a lawsuit as the guest author of a ghostwritten review on obesity commissioned by Wyeth-Ayerst regarding long-term, off-label use of the dangerous "fen-phen" combination (fenfluramine
One of them--Fen-Phen, a combination of phentermine and fenfluramine--was linked to heart-valve disorders, but those problems were attributed only to the pill's fenfluramine