10) Historically, the limitations have been due to a variety of concerns these include valvulopathy associated with fenfluramine
and dexfenfluramine, the abuse potential and psychiatric side effects associated with rimonabant, and, most recently, cardiac adverse events associated with sibutramine.
One component of that medication, fenfluramine
, was taken off the market; the other, phentermine (now a component of Qnexa) is generally considered safe at low doses.
To the best of our knowledge, the concern with the heart valves was limited to fenfluramine
and dexfenfluramine," two fen-phen ingredients that were banned from the market in 1997, said Colman, who started in his division 15 years ago as risks from the treatment were emerging.
3 Drug-and toxin-induced PAH, caused by certain drugs and toxins including aminorex, fenfluramine
, dexfenfluramine, and toxic rapeseed oil have been associated with the development of PAH.
Previously, severe heart valve disorders have been reported in patients receiving a combination of the anorectic drugs such as fenfluramine
and phentermine (8, 9).
Vascular heart disease associated with fenfluramine
Now, the researchers have defined a circuit in the brain that explains the ways fenfluramine
, a component of Fen-phen, suppresses appetite.
While being told that their sons would undergo only a safe test to discover if they might have any medical problems, the children were instead subjected to doses of the drug fenfluramine
(one of the components of the banned drug Fen-Phen).
Wyeth marketed the dangerous "fen" half of it--the drugs fenfluramine
and dexfenfluramine, sold under the brand names Pondimin and Redux.
Ironically, the FDAMA was enacted only two months after the popular diet drugs fenfluramine
and dexfenfluramine were withdrawn from the market because of adverse events linked to their off-label use.
The objective of the analysis presented in this article is to examine the public disclosure of serious side effects associated with the combined use of fenfluramine
and phentermine, also known as fen-phen, a prescription weight loss drug cocktail produced and actively promoted by Robins Pharmaceuticals and Wyeth-Ayerst, both divisions of American Home Products.
In addition, certain medications, particularly diet pills such as Fen-Phen (a combination of fenfluramine
and phentermine that was taken off the market several years ago) may cause this condition.