fenfluramine


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fenfluramine

 [fen-flo̳r´ah-mēn]
an appetite suppressant used as the hydrochloride salt; unlike the amphetamines, it seems to depress rather than stimulate the central nervous system.

fenfluramine

Pondimin®, Redux® Internal medicine An adrenergic appetite suppressing–anorectic amphetamine congener, which, unlike amphetamine, depresses the CNS; fenfluramine ↑ serotonin levels and imparts a sensation of fullness from a lower intake of food and was prescribed as a short-term adjunct in obesity; it was withdrawn from the market following its association with heart valve abnormalities and other cardiac complications Adverse effects Pulmonary HTN, attributed either to serotonic vasoconstriction or altered depolarization of pulmonary vascular smooth muscle membrane. See Fen/Phen.

fenfluramine

A drug used in the management of obesity. It is thought to work by producing a sense of having eaten enough (satiety) rather than by suppressing appetite. There is evidence that fenfluramine may be associated with heart valve disease and PULMONARY HYPERTENSION and it is now rarely used.
References in periodicals archive ?
Two issued patents cover the proprietary synthetic process used to manufacture fenfluramine
Unlike fenfluramine and dexfenfluramine, phentermine was not withdrawn from the market at that time.
The drug was generally well-tolerated in the study, with adverse events consistent with those observed previously and the known safety profile of fenfluramine.
Risk of valvular heart disease associated with use of fenfluramine. BMC Cardiovasc Disord.
With the exception of fenfluramine, all drugs approved before 1996 were structurally related to amphetamine, although they differed in their effects on enhancing the turnover of norepinephrine and dopamine, thus differing in their abuse potential.
Lelord, "Urinary dopamine metabolites as indicators of the responsiveness to fenfluramine treatment in children with autistic behavior," Journal of Autism and Developmental Disorders, vol.
A greater prolactin response to fenfluramine was associated with treatment resistance in one study [30].
Drugs used for treatment include thyroid hormones, fenfluramine. Currently phentermine, topiramate, serotonin agonists, cannibinoid receptors antagonists are the known anti obesity preparations.
Other serotonergic medications previously used for weight loss, such as fenfluramine, stimulated the serotonin 2b receptor, which may have contributed to an increased risk of cardiac valve disease.
The year after chairing the panel, Pi-Sunyer was identified in a lawsuit as the guest author of a ghostwritten review on obesity commissioned by Wyeth-Ayerst regarding long-term, off-label use of the dangerous "fen-phen" combination (fenfluramine and phentermine).
One of them--Fen-Phen, a combination of phentermine and fenfluramine--was linked to heart-valve disorders, but those problems were attributed only to the pill's fenfluramine component.