fen-phen


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fen-phen

(fĕn′fĕn′)
n.
A combination of two drugs, fenfluramine hydrochloride and phentermine, formerly prescribed for weight loss but withdrawn from the market in 1997 because of potentially dangerous side effects.

Fen-Phen

Cardiology A once-popular combination of 2 anorectic agents, fenfluramine and phentermine; the theoretical advantage of using 2 different agents is that the dose of each agent could be lowered Adverse effects The fen-phen combination is associated with valvular heart disease and fatal pulmonary HTN; it was withdrawn from the market. See Fenfluramine.
References in periodicals archive ?
Crary notes that he has successfully used medication to improve the heart's pumping power in some fen-phen patients who have serious valve disease.
She discovered the link to fen-phen and fought to get the evidence reported to Wyeth and the FDA.
Made up of fenfluramine and phentermine, fen-phen was widely prescribed in the 1990s as a safe and effective way to lose weight.
The fen-phen thing collapsing will turn out to be a big driver in this segment," he notes.
Now, the researchers have defined a circuit in the brain that explains the ways fenfluramine, a component of Fen-phen, suppresses appetite.
To illustrate the types of complications that bedevil back-end opt-out rights, Part II describes a massive class action lawsuit filed on behalf of millions of users of the diet drugs known as fen-phen, which were found to cause heart problems.
He insists that Wyeth has largely pushed its fen-phen and hormone therapy troubles into boxes that it can measure, wrap up and put aside.
In the 1990s, fen-phen was widely prescribed, with as many as 18 million prescriptions written in 1996 alone (Pitts, Crosby, Laufenberg, Meidinger, & Monson, 1998).
For example, in the Fen-Phen product liability trial, the cost of discovery for a pharmaceutical company retrieving records from backup tapes was estimated at almost $2 million.
Despite the eye-popping headlines about billion-dollar fen-phen verdicts or David v.
In addition, certain medications, particularly diet pills such as Fen-Phen (a combination of fenfluramine and phentermine that was taken off the market several years ago) may cause this condition.
In 1996 the FDA approved the diet drug Redux--which later had to be withdrawn, along with another weight-loss medication involved in the deadly fen-phen scandal--after its lead reviewer warned of "severe life-threatening risk.