fen-phen


Also found in: Dictionary, Acronyms, Wikipedia.

fen-phen

(fĕn′fĕn′)
n.
A combination of two drugs, fenfluramine hydrochloride and phentermine, formerly prescribed for weight loss but withdrawn from the market in 1997 because of potentially dangerous side effects.

Fen-Phen

Cardiology A once-popular combination of 2 anorectic agents, fenfluramine and phentermine; the theoretical advantage of using 2 different agents is that the dose of each agent could be lowered Adverse effects The fen-phen combination is associated with valvular heart disease and fatal pulmonary HTN; it was withdrawn from the market. See Fenfluramine.
References in periodicals archive ?
Of course, it almost goes without saying that the ABA's Model Rules already prohibit attorneys from bringing false claims, (76) unnecessarily multiplying litigation, or resorting to the sort of fraudulent mass-screening techniques seen in asbestos and fen-phen. Further, many states have applicable standards far more stringent than those suggested in the Model Rules.
Wyeth's "medical education" campaign for Fen-Phen was a model of the genre.
Fen-Phen is the street name for the Fenfluramine-Phentermine combination.
Arena scientists explain that the difference between fen-phen and lorcaserin is that lorcaserin goes after just one serotonin receptor known as 2C and specifically avoids the 2B receptor that is active in the heart and may lead to cardiovascular risk.
Weight-loss drugs have had a troubled history, starting in 1997 when the medication known as fen-phen was withdrawn from the market after being linked to fatal heart-valve problems.
Elsewhere, the FDA won't re-examine safety data from fen-phen, the recalled diet drug tied to heart damage, as they review a new generation of weight-loss pills led by Vivus Inc.'s (Mountain View CA) Qnexa that use some of the same ingredients.
* $3.75 billion settlement in Fen-phen litigation; email: "Do I have to look forward to spending my waning years writing checks to fat people worried about a silly lung problem?"
The text includes in-depth analyses of well-known case studies in crisis communication, including terrorist attacks in London and Madrid, Hurricane Katrina, the Virginia Tech shootings, and the fen-phen diet drug crisis.
One former Wyeth executive once told us that the $21 billion in charges taken a decade ago for the Fen-phen diet pill litigation meant there were fewer funds for such activities as licensing or acquiring drugs from other companies.
In April, Gallion, 58, and Cunningham, 54, already disbarred as lawyers, were convicted of defrauding over 400 clients, the intended beneficiaries of a $200 million settlement with the manufacturer of fen-phen, a diet drug found to cause serious heart damage.
Further, papers promoting dangerous drugs such as Fen-Phen (made by Wyeth), which was later withdrawn because of fatal heart and valve problems that it caused, were written by Wyeth--subsequently scientists were paid large sums to lend their names to the articles as their authors!
Controversies include heart valve problems associated with the use of the diet drug combo Fen-Phen, or the increased suicide risk in anti-depressant usage, the heart attack and stroke risk caused by Vioxx, Celebrex and Bextra, and the diabetic drug Avandia has been noted to have an increased risk of heart attack.