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a calcium channel blocking agent used as a vasodilator in treatment of hypertension.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


Cardioplen (UK), Felotens (UK), Keloc (UK), Neofel (UK), Plendil, Renedil (CA), Vascalpha (UK)

Pharmacologic class: Calcium channel blocker

Therapeutic class: Antihypertensive, antianginal

Pregnancy risk category C


Impedes extracellular calcium ion movement across membranes of myocardial muscle cells, depressing myocardial contractility and impulse formation; slows impulse conduction velocity and dilates coronary arteries and peripheral arterioles. Net effect is reduced cardiac workload and lower blood pressure.


Tablets (extended-release): 2.5 mg, 5 mg, 10 mg

Indications and dosages


Adults: Initially, 5 mg P.O. daily. Depending on response, may decrease to 2.5 mg or increase to a maximum of 10 mg P.O. daily at 2-week intervals.

Dosage adjustment

• Hepatic impairment

• Elderly patients

Off-label uses

• Heart failure

• Angina pectoris or vasospastic (Prinzmetal's) angina


• Hypersensitivity to drug


Use cautiously in:

• cardiac disease, arrhythmias, severe hepatic or renal impairment

• elderly patients

• pregnant or breastfeeding patients

• children (safety not established).


• Give without regard to meals.

• Make sure patient swallows tablet whole without crushing or chewing.

Adverse reactions

CNS: headache, drowsiness, dizziness, syncope, nervousness, anxiety, psychiatric disturbances, paresthesia, insomnia, asthenia, confusion, irritability

CV: chest pain, peripheral edema, hypotension, palpitations, tachycardia, angina, arrhythmias, myocardial infarction, atrioventricular block

EENT: rhinorrhea, sneezing, pharyngitis

GI: nausea, vomiting, diarrhea, constipation, abdominal discomfort, dyspepsia, abdominal cramps, flatulence, dry mouth

Hematologic: anemia

Musculoskeletal: back pain

Respiratory: bronchitis

Skin: dermatitis, rash, pruritus, urticaria, erythema

Other: dysgeusia, gingival hyperplasia, facial edema, thirst, warm sensation


Drug-drug. Antifungals, cimetidine, erythromycin, propranolol, ranitidine: increased felodipine blood level, increased risk of toxicity

Barbiturates, hydantoins: decreased felodipine blood level

Beta-adrenergic blockers, digoxin, disopyramide, phenytoin: bradycardia, conduction defects, heart failure

Fentanyl, nitrates, other antihypertensives, quinidine: additive hypotension

Nonsteroidal anti-inflammatory drugs: decreased antihypertensive effects

Drug-food. Grapefruit juice: increased felodipine blood level and effects

Drug-behaviors. Acute alcohol ingestion: additive hypotension

Patient monitoring

Don't give to patient with heart block unless he has a pacemaker.

Use extreme caution when administering to patients with pulmonary hypertension, renal insufficiency, heart failure, or compromised ventricular function (especially those receiving beta-adrenergic blockers concurrently).

• Monitor fluid intake and output, and weigh patient daily.

• Monitor ECG and vital signs. Assess for signs and symptoms of heart block.

• Assess for reflex tachycardia, angina, and sustained hypotension.

• Check hepatic profile and alkaline phosphatase level in patients with hepatic impairment.

Patient teaching

• Tell patient drug controls but doesn't cure high blood pressure, so he should keep taking it even if he feels well.

• Instruct patient to move slowly when rising, to avoid light-headedness or dizziness from sudden blood pressure decrease.

• Explain that exercise and hot weather may increase drug's hypotensive effects.

• Tell patient to report peripheral edema, persistent headache, or flushing.

• Advise patient to use hard candy or gum if dry mouth or thirst occurs.

• Tell female patient to inform prescriber if she is pregnant or breastfeeding.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, foods, and behaviors mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved


A calcium channel blocker that acts as a vasodilator, used to treat hypertension and angina pectoris.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


Plendil® Cardiology A beta-blocking antihypertensive
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
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Felodipine was effective at reducing the build-up of harmful proteins in the mice with the Huntington's and Parkinson's disease mutations and in the zebrafish dementia model.
Grapefruit juice increased the oral bioavailability of felodipine by inhibition of CYP3A4-mediated presystemic drug metabolism.
It was as though everyone--those who drank alcohol plus grapefruit juice and those who drank just grapefruit juice--had gotten at least three times the dose of felodipine. (1)
The Felodipine Event Reduction (FEVER) Study: A randomized long-term placebo-controlled trial in Chinese hypertensive patients.
According to the contract, Recordati will purchase the rights of AstraZeneca's Seloken / Seloken ZOK (metoprolol succinate) and associated Logimax fixed dose combination (metoprolol succinate and felodipine) treatments.
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Potentially interacting medications including felodipine and atorvastatin were stopped, and she started 12 weeks of VIEKIRA PAK without ribavirin on 21 March.
Schum Bixa orellana Lipstick tree Pentoxyresorufin, Benzyloxyresorufin Capsicum annuum Red chilli pepper Daunorubicin, Rhodamine-123 Carica papaya Pawpaw Digoxin, amiodarone Catha edulis Khat Dextromethorphan Centella asiatica Centella Tolbutamide Citrus aurantifolia Lime Bupropion (Christm.) Swingle Felodipine Citrus aurantium Sour orange Vinblastine L.
Only the study conducted by Elhebir [16] demonstrated the impact of NDHP (diltiazem and verapamil), highly vascular selective DHP (felodipine and lercanidipine), and other DHP (amlodipine and nifedipine) on LUTS.
* Blood pressure medications known as calcium channel blockers, such as felodipine (Plendil[R]) and nifedipine (Adalat[R], Procardia[R])
Calcium channel blockers are generally considered to be first line, particularly dihydropyridine calcium channel antagonists such as nifedipine, isradipine, felodipine and amlodipine.
The pharmacist misread the order as Plendil (felodipine), a calcium channel blocker for treatment of hypertension.