feedback inhibition


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Related to feedback inhibition: Allosteric regulation

feed·back in·hi·bi·tion

inhibition of activity by an end product of the pathway of which that activity is a part; for example, thyroliberin stimulates thyroglobulin production, and thyroglobulin decreases thyrotropin formation.

feedback inhibition

n.
A cellular control mechanism in which an enzyme that catalyzes the production of a particular substance in the cell is inhibited when that substance has accumulated to a certain level, thereby balancing the amount provided with the amount needed.

feed·back in·hi·bi·tion

(fēd'bak in'hi-bish'ŭn)
Inhibition of activity by an end product of the pathway of which that activity is a part.
Synonym(s): feedback mechanism.

feedback inhibition

the inhibition of the synthesis of a molecule by a control mechanism initiated by the increase in concentration of that molecule.

Kiliani,

H., German chemist, 1855-1945.
Kiliani-Fischer reaction - Synonym(s): Kiliani-Fischer synthesis
Kiliani-Fischer synthesis - a synthetic procedure for the extension of the carbon atom chain of aldoses by treatment with cyanide. Synonym(s): feedback inhibition; Kiliani-Fischer reaction
References in periodicals archive ?
Rao and Ravishankar [13] reported that it was possible that the by-products in the spent medium could lead to unwanted feedback inhibition towards the products of interest.
Third, in addition to the classical angiotensin II-dependent effects on natrium retention, blood pressure, induction of thirst, and others, angiotensin II also acts on the release mechanisms of renin, thereby forming a feedback inhibition of the system (Figure 1).
If the morning cortisol is less than 5 mcg/ dL, or if there is more than a 50% decrease in the baseline morning cortisol then cortisol production is considered suppressible.(5) Pituitary Cushing's Disease is only somewhat resistant to feedback inhibition whereas ectopic tumors producing ACTH are usually completely resistant to feedback inhibition.
Some evidence suggests that glucocorticoids play a role in hippocampal inhibition of anticipatory responses, as lesions can block feedback inhibition of the HPA axis by the synthetic steroid dexamethasone (Magarinos et al.