fatty change

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Related to fatty change: fatty metamorphosis

fat·ty met·a·mor·pho·sis

the appearance of microscopically visible droplets of fat in the cytoplasm of cells.
See also: fatty degeneration.
Synonym(s): fatty change
Farlex Partner Medical Dictionary © Farlex 2012


A pattern of reversible cell injury resulting from hypoxia, toxic or metabolic insults, diabetes mellitus, obesity, and protein malnutrition, which consists of an accumulation of droplets of triglcerides/neutral fat in various solid organs—classically, the liver—and most common in alcoholics in whom the changes regress with abstention from alcohol. Fatty changes may also occur in other organs (e.g., heart, muscle, kidney).
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

fatty change

Any abnormal accumulation of fat within parenchymal cells. It may occur in the heart or other organs. When seen in the liver, it often is a result of excessive and prolonged alcohol intake or obesity.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
The photomicrography section of the liver's 40% cassava flour and 60% wheat flour in first week, stained with H/E (X 600) shows moderate fatty change (MFC) and granulated cytoplasm (GC).
I consider a four-hour insulin profile the single most important laboratory test for assessing not only the glucose metabolism but also for the early detection and quantification of the insulin-toxic states, such as obesity, fatty change of the liver, prediabetes, diabetes, prehypertension, hypertension, neuropathy, incipient renal failure, and cardiovascular events.
i Gr ii Gr iii Gr iv Hepatic cord pattern Normal Normal Normal Normal Sinusoidal dilatation _ + ++ +++ Focal fatty change _ + ++ + Vacuolization of hepatocytes _ ++ ++ ++ Pyknosis of hepatocytes _ ++ ++ ++ Apoptosis _ _ _ _ Site and Effects Remarks Hepatic cord pattern No effect observed Sinusoidal dilatation Marked dilatation in grp iv and in other treated grps Focal fatty change Vacuolization of hepatocytes Equal vacuolization in hepatocytes in all grps Pyknosis of hepatocytes Equal magnitude of damage in all grps Apoptosis No apoptosis was observed in any grp
In case of organophosphorus and organochlorine poisoning major histopathological changes are centrilobular necrosis and sinusoidal dilatation, in carbamate poisoning sinusoidal dilatation is major histopathological change, fatty changes is predominant among alcohol poisoning, and combined alcohol and insecticidal poisoning major histopathological changes are fatty change, combined centrilobular necrosis and fatty change, combined sinusoidal dilatation.
Histological examination of liver using hematoxylin and eosin and Oil Red O staining showed increased accumulation of inflammatory cells and LDs, with macrovesicular fatty changes and hepatocyte ballooning in liver of HFFD group of rats.
In sections of C[CL.sub.4] + atorvastatin (5 mg/kg) treated livers there was pronounced fatty changes in the centers of the hepatic lobules and lymphocellular infiltrations in the periportal fields.
weeks induced macro and micro fatty changes (steatosis), and moderate fibrosis without formation of septa.
In spite of pretreatment with Livokin, the liver sections showed zone 3 necrosis and fatty changes and Octogen pretreatment showed zone 3 necrosis and periportal fatty changes more in between centrizonal and periportal areas as well as portal areas of necrosis.
The liver had mild fatty changes, activated Kupffer cells, and slight lymphoid infiltration in the portal areas.
"These fatty changes can be reversed but if they're not spotted can lead to cirrhosis and in some cases liver cancers.