fatty change

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Related to fatty change: fatty metamorphosis

fat·ty met·a·mor·pho·sis

the appearance of microscopically visible droplets of fat in the cytoplasm of cells.
See also: fatty degeneration.
Synonym(s): fatty change


A pattern of reversible cell injury resulting from hypoxia, toxic or metabolic insults, diabetes mellitus, obesity, and protein malnutrition, which consists of an accumulation of droplets of triglcerides/neutral fat in various solid organs—classically, the liver—and most common in alcoholics in whom the changes regress with abstention from alcohol. Fatty changes may also occur in other organs (e.g., heart, muscle, kidney).

fatty change

Any abnormal accumulation of fat within parenchymal cells. It may occur in the heart or other organs. When seen in the liver, it often is a result of excessive and prolonged alcohol intake or obesity.
References in periodicals archive ?
I consider a four-hour insulin profile the single most important laboratory test for assessing not only the glucose metabolism but also for the early detection and quantification of the insulin-toxic states, such as obesity, fatty change of the liver, prediabetes, diabetes, prehypertension, hypertension, neuropathy, incipient renal failure, and cardiovascular events.
Rana M A and Jawary A H 2011 (10) demonstrated cisplatin induced hepatotoxicity in rats which was manifested as severe fatty changes, congestion, and dilatation of portal vessels & central veins along with multiple necrotic foci.
of liver of group ii albino rat showing congestion (a & b), Vacuolization and fatty changes (c), Pyknotic nuclei (d) h & e stain x 400.
4] for four weeks induced a moderate fibrosis without formation of septa and macro and micro fatty changes (Steatosis).
In spite of pretreatment with Livokin, the liver sections showed zone 3 necrosis and fatty changes and Octogen pretreatment showed zone 3 necrosis and periportal fatty changes more in between centrizonal and periportal areas as well as portal areas of necrosis.
The crude liver weight, which was increased after PCM administration may be due to haemorrhages, hydropic degeneration and fatty changes associated with necrosis.
So useful in detection of calcification, hemorrhage, fatty changes clear and purulent fluid.
During efforts to produce a cirrhosis of the liver in animals with alcohol, as well as during experiments designed simply to ascertain the effects of alcohol on its structure, an accumulation of the fat in the liver cells has been found so commonly as the main alteration that a relation between alcohol and fatty changes in the liver has long been recognized.
Out of 5 subjects having grade III fatty changes, all 5 (100%) had increased CIMT.
Ultrasound abdomen revealed hepatomegaly with fatty changes in liver, normal portal and hepatic veins with normal pattern of blood flow.