These larger motor units are associated with larger, fatigable
(glycolytic) Type II muscle fibres.
Esto podria comprometer la capacidad metabolica del tejido y reducir su rendimiento, transformando al musculo esqueletico en un tejido facilmente fatigable
, lo cual limitara con el tiempo la movilizacion del paciente y su capacidad para hacer ejercicio.
Her gait was normal, and she was able to walk a long distance although she was fatigable
. She suffered from some deep pain in her legs, particularly at rest.
Both body and soul impinge upon the mind, that fragile and fatigable
network of human meeting points that makes demands of a given individual throughout life.
Congenital myasthenic syndromes (CMSs [MIM 608931]) represents a group of clinically and genetically heterogeneous disorders caused by impaired neuromuscular junction (NMJ) transmission leading to fatigable
weakness.[sup] Conventionally, CMS were classified on the basis of the location of a mutated protein as presynaptic, synaptic basal lamina-associated, or postsynaptic.
It often affects the ocular (>50%; ptosis, diplopia), bulbar (15%; dysarthria, dysphagia, fatigable
chewing), limb (<5%; usually proximal weakness), and respiratory muscles.
CMS is a rare neuromuscular disease comprising a spectrum of genetic defects and is characterised by fatigable
weakness of skeletal muscles with onset at or shortly after birth or early childhood; in rare cases symptoms may not manifest themselves until later in childhood.