fast atom bombardment


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fast atom bombardment

A technique of mass spectrometry that uses a beam of neutral atoms (created by neutralising ions of about 5 keV energy) to sputter sample molecules from a liquid held on the surface of a beam-intersecting sample probe. The impacting atoms deposit energy into the semivolatile matrix, causing desorption of ions, neutral molecules, and clusters of solvent and sample molecules. Desolvation follows desorption, and molecules (M) are usually ionised in a process of protonation to form M H. The mass spectra usually contain a large background of ions from the energy-moderating solvent (e.g., glycerol).
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We describe in this study the isolation of the 39-O-demethyl rapamycin metabolite from pig liver microsomes and the structural identification of this compound by fast atom bombardment (FAB) and electrospray tandem mass spectrometry (MS-MS).
(3) Nonstandard abbreviations: FKBP, FK-506 binding protein; FAB, fast atom bombardment; MS, mass spectrometry; MLR, mixed lymphocyte reaction; and RT, retention time.