Por tanto, se demostro sinergia al combinar el farnesol
con medicamentos antifungicos, lo cual mejora el efecto farmacologico en especimenes previamente resistentes.
, an isoprenoid, improves metabolic abnormalities in mice via both PPARalpha-dependent and -independent pathways.
Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol
. Applied Environ Microbiology 2001; 67: 2982-2992.
In the late steps of JH synthesis, conversion of FPP to farnesol
(FOL) is catalyzed in D.
Crowell, "Inhibition of pancreatic cancer growth by the dietary isoprenoids farnesol
and geraniol," Lipids, vol.
Shortly after its discovery, farnesol
derivatives were found to be effective activators, where FXR was originally named after .
(39) These include liver X receptor, hepatocyte nuclear factor-4 alpha (HNF-4 alpha), farnesol
X receptor, and peroxisome proliferators-activated receptor (PPARs).
RXRG heterodimerizes with the farnesol
X receptor (FXR) [or bile acid receptor (BAR)], the liver X receptors (LXRs), and the peroxisome proliferator-activated receptors (PPARs).
The addition of farnesol
to cells treated with the combination abolished the effects of the N-BPs/FTI combination on apoptosis and on the activity of the signaling molecules, suggesting that the synergistic growth-inhibitory and proapoptotic effects produced by the N-BPs/FTI combination involved the inhibition of both Erk and Akt survival pathways acting in these cells in a Ras-dependent fashion .
Petro, "Exogenous farnesol
interferes with the normal progression of cytokine expression during candidiasis in a mouse model," Infection and Immunity, vol.
(6,7) Examples of these substances include those that target bacterial attachment (lactoferrin and salicylic acid) and those that block formation or cause degradation of the biofilm matrix (xylitol and farnesol