fardel


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far·del

(far'del),
The total measurable penalty that is incurred as a result of the occurrence of a genetic disease in one individual; one of two major quantitative considerations in the prognostic aspects of genetic counseling, the other being risk of occurrence. The fardel roughly measures the duration and the severity of the penalty, that is, the integral of the total time-intensity function; for example, color blindness has a low intensity of penalty throughout life, anencephaly causes intense distress for a brief time, Alzheimer disease is intermediate in both respects but the fardel is greater.
[M.E., fr. O. Fr., fr. Ar. fardah, bundle]

far·del

(fahr'del)
The total measurable penalty that is incurred as a result of the occurrence of a genetic disease in one individual; one of two major quantitative considerations in the prognostic aspects of genetic counseling, the other being risk of occurrence.
[M.E., fr. O. Fr., fr. Ar. fardah, bundle]
References in periodicals archive ?
Al igual que en otras labores, el coste de esta operacion era fijo--al menos hasta 1587--, cada fardel rehecho suponia 20 mrs.
Fortunately, there is also a glossary for elusive words which some children will relish such as: 'ouches' (jewels), 'portage' (portholes), 'dewberries' (blackberries), and 'fardels' (burdens), the latter being things Hamlet resents in the famous 'to be, or not to be' soliloquy.
Lemarie, A., Morzadec, C., Merino, D., Micheau, O., Fardel, O., Vernhet, L., 2006.
La primera traza que nos describe el protagonista es la de "sangrar el avariento fardel".
Readings of Shakespeare in part 1 occasionally show the strain of engaging too many powerful readers, but this does little to detract from the force of arguments that link a closely read element, like Perdita's "fardel," to generic resolution, and beyond that, to a cultural contradiction--in this case, the need to reconcile loss as a necessary expenditure, a deferral of profit now normalized in the modern concept of "investment" (94).
progesterone, medroxyprogesterone acetate, and RU486 antiprogestin) (Fardel et al., 1996), are not transported but rather act as strong modulators of drug efflux (Kimura et al., 2004).
Lemarie A, Bourdonnay E, Morzadec C, Fardel O, Vernhet L.
Lemarie A, Lagadic-Gossmann D, Morzadec C, Allain N, Fardel O, Vernhet L.
It takes "oceans of technique and discipline and rigour," he argues, to present Hamlet's bumps and curves without the fardels of foisted subtext:
"Who would fardels bear", muses the indecisive Shakespearean hero, "To grunt and sweat under a weary life, /But that the dread of something after death,/The undiscovered country, from whose bourn/No traveller returns, puzzles the will,/And makes us rather bear those ills we have/Than fly to others that we know not of?." (Hamlet, 3.1.76-82).