the accumulation of abnormal low-density lipoproteins (β-lipoproteins) in the blood.
familial dysbetalipoproteinemia familial hyperlipoproteinemia, type III.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
familial dysbetalipoproteinemiaBroad beta lipoproteinemia, hyperlipoproteinemia type III Metabolic disease An uncommon 1:1,000 to 10,000 AD condition with a defective apoE–the apoE2/2 phenotype, poor catabolism of beta-migrating remnants, and ↑ production of TG-rich lipoproteins–eg, VLDL Clinical Palmoplantar tuberoeruptive xanthomas, ASHD < age 50, peripheral vascular and CAD, which may be accompanied by hyperthyroidism Lab ↑ TGs, ↑ cholesterol, floating beta lipoproteins Management Diet–weight loss, exercise, drugs–eg bile acid-binding resins and nicotinic acid; in post-menopausal ♀, low-dose estrogens
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.