familial combined hyperlipidemia


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familial combined hyperlipidemia

Metabolic disease A common–1:300 AD disorder with ↑ TGs and/or cholesterol Lab ↑ apoB, ↑ LDL-C, ↑ VLDL-C, mild ↓ HDL-C, apoA1 Clinical CAD, first MI as early as age 40, overweight, HTN Management Diet–weight loss, exercise, lipid-lowering drugs; smoking is forbidden as it exacerbates ASHD
References in periodicals archive ?
Megiorni et al., "Genetic variants in adipose triglyceride lipase influence lipid levels in familial combined hyperlipidemia," Atherosclerosis, vol.
Muller-Myhsok et al., "Support for linkage of familial combined hyperlipidemia to chromosome 1q21-q23 in Chinese and German families," Clinical Genetics, vol.
Additionally, among those classified as probable or possible HFH, there may be some patients with familial combined hyperlipidemia (FCH), as "combined" is not always an accurate descriptor of this condition, in which increased TGs are not always observed.
[3] Nonstandard abbreviations: HFH, heterozygous familial hypercholesterolemia; CVD, cardiovascular disease; LDL-C, LDL-cholesterol; Lp(a), lipoprotein( a); CAD, coronary artery disease; FCH, familial combined hyperlipidemia; TG, triglyceride; BMI, body mass index; TC, total cholesterol; HDL-C, HDL-cholesterol; HR, hazard ratio; and CI, confidence interval.
Complex genetic contribution of the Apo AI-CIII-AIV gene cluster to familial combined hyperlipidemia. J Clin Invest 1997;99:953-61.
Plasma lipoproteins in familial combined hyperlipidemia and monogenic familial hypertriglyceridemia.

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