familial amyloidosis


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fa·mil·i·al am·y·loid neu·rop·a·thy

[MIM*105120, various kinds]
a disorder in which various peripheral nerves are infiltrated with amyloid and their functions disturbed; an abnormal prealbumin is also formed and is present in the blood; characteristically, it begins during midlife and is found largely in patients of Portuguese descent; autosomal dominant inheritance. Other rare clinical types occur.
Farlex Partner Medical Dictionary © Farlex 2012

familial amyloidosis

The only inherited form of amyloidosis. In this variant of the disease, transthyretin is manufactured by the liver and deposits in a wide variety of tissues, causing them to malfunction.
See also: amyloidosis
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Trojaborg, "Familial amyloidosis with cranial neuropathy and corneal lattice dystrophy," Journal of Neurology, Neurosurgery and Psychiatry, vol.
Homozygous familial amyloidosis, Finnish type: demonstration of glomerular gelsolin-derived amyloid and non-amyloid tubular gelsolin.
In ATTR and all other forms of familial amyloidosis, the variant structure of the amyloid precursor is the pivotal factor in amyloidogenesis,[16] TTR is a carrier protein for thyroid hormone and retinol binding protein.

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