familial aggregation


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Related to familial aggregation: proband

aggregation

 [ag″rĕ-ga´shun]
1. massing or clumping of materials together.
2. a clumped mass of material.
familial aggregation the occurrence of more cases of a given disorder in close relatives of a person with the disorder than in control families.
platelet aggregation platelet agglutination.

fa·mil·i·al ag·gre·ga·tion

occurrence of a trait in more members of a family than can be readily accounted for by chance; presumptive but not cogent evidence of the operation of genetic factors.

fa·mil·i·al ag·gre·ga·tion

(fă-mil'ē-ăl ag'rĕ-gā'shŭn)
Occurrence of a trait in more members of a family than can be readily accounted for by chance; presumptive but not cogent evidence of the operation of genetic factors.
References in periodicals archive ?
This study confirms our initial hypothesis of the existence of familial aggregation of CKD in individuals with hypertension and/or type 2 diabetes mellitus, indicating that familial predisposition to these diseases is an independent risk factor for kidney failure within this sample of the Brazilian population.
Familial aggregation of end-stage kidney disease in Brazil.
Familial aggregation of type 2 (non-insulin-dependent) diabetes mellitus in south India; absence of excess maternal transmission.
Maternal effect and familial aggregation in a type 2 diabetic Moroccan population.
Familial aggregation of dyslexia phenotypes: paired correlated measures.
Thus far, there has been no attempt to examine whether individual differences in coincidence timing skills exhibit familial aggregation. This study used twins to examine individual variation in coincidence timing skills and to attempt to partition the variation into genetic and environmental components.
"This nationwide study documented strong familial aggregation of pyloric stenosis, with a nearly 200-fold in-crease among monozygotic twins and 20-fold increase among siblings.
Segregation analysis is a statistical methodology aimed at determining if a major gene or genes could cause the observed familial aggregation of a disease by comparing the fit of both genetic and nongenetic models to family data.
Bradley added that a number of recent studies have also shown a familial aggregation of pain sensitivity.
As the general principles of genetics indicate hereditary factors are likely involved in a disease with familial aggregation over two generations.
Setting trauma-related and obsessive-compulsive spectrum disorders off on their own makes sense because the "longitudinal outcomes, comorbidities, familial aggregations, and underlying biology" suggest the conditions are different from anxiety disorders, said Dr.

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