acantholysis

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acantholysis

 [ak″an-thol´ĭ-sis]
disruption of the intercellular connections between keratinocytes of the epidermis, caused by lysis of intercellular cement substance. It is associated with the formation of epidermal vesicles in such conditions as pemphigus vulgaris, pemphigus foliaceus, and other skin disorders.

ac·an·thol·y·sis

(ak-an-thol'i-sis), Avoid the mispronunciation acantholy'sis.
Separation of individual epidermal keratinocytes from their neighbor, as in conditions such as pemphigus vulgaris and Darier disease.
[acantho- + G. lysis, loosening]

acantholysis

A histologically defined condition characterised by a pathologic disruption of intercellular bridges between keratinocytes in the squamous epithelium of mucocutaneous surfaces, resulting in intraepithelial vesication and/or separation of the epithelium from the subjacent dermis.

Acantholysis is a misnomer that is retained because it paraphrases a process that cannot be fully defined at the molecular level. It has been applied to a variety of unrelated conditions that share the loss of intraepidermal cohesion, including those in which the loss is clearly the consequence of severe cell damage.

acantholysis

Dermatology The pathologic disruption of intercellular bridges between keratinocytes in the squamous epithelium of mucocutaneous surfaces, resulting in intraepithelial vesicles Diseases with Pemphigus vulgaris, benign familial pemphigus (Hailey-Hailey disease), Darier's disease, staphylococcal scalded-skin syndrome. See Pemphigus vulgaris, Tombstone appearance.

ac·an·thol·y·sis

(ak'an-thol'i-sis)
Separation of individual epidermal keratinocytes from their neighbors, as in conditions such as pemphigus vulgaris and Darier disease.
[acantho- + G. lysis, loosening]

acantholysis

Splitting apart of layers of cells in the epidermis often top form a blister.

ac·an·thol·y·sis

(ak'an-thol'i-sis)
Separation of individual epidermal keratinocytes from their neighbors.
[acantho- + G. lysis, loosening]