The results showed the cancer-detection rate was significantly higher in the DBT group than the DM group, and the false-positive
rate was significantly lower in the DBT group compared with the DM group.
The reason this apparent false-positive
rate from this study is so high is mostly because the Kepler team has been very generous with the last few data releases with what has been called a 'candidate'," Morton says.
Because no clinical lab test is perfect, any clinician who runs urine drug screens will encounter a false-positive
This is best illustrated by hydrocodone, which cross-reacts with the oxycodone immunoassay per the package insert and leads to 56% of the oxycodone false-positive
results (from hydrocodone measured by LC-MS/MS).
For each screening episode, the outcome was: no false-positive
(NFP), false positive not requiring biopsy (FPA) and FPB.
After distributing the unknowns by the observed ratios of objects, the team arrived at the 35 percent false-positive
responses were defined as a "malignant" or "suspicious" general category response, chosen for the cases in which the specific reference diagnosis was "specific infections/granulomatous inflammation.
With chest X-rays, there was a 9% chance of a false-positive
after one test, and a 15% chance after two, the researchers report in the Annals of Internal Medicine.
On September 10, CDC notified all state health departments of the potential problem and initiated an investigation into the cause of the false-positive
test results (1).
Sensitivity was defined as the percentage of positive examinations among women diagnosed with breast cancer, and the false-positive
rate as the percentage of positive examinations among women without a breast cancer diagnosis.
If unnecessary diagnostic procedures are performed based on false-positive
findings, "substantial risk can be associated with a multiple-modality periodic cancer screening regimen," Dr.
However, only [approximately equal to] 10% of positive results were confirmed by reverse transcription-PCR, which suggests frequent false-positive
results or viral clearance.