margin of safety

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an edge or border.
gingival margin gum margin.
gum margin the border of the gingiva surrounding, but unattached to, the substance of the teeth.
margin of safety a calculation that takes the highest animal no observed adverse effect level and estimates a maximum safe level of exposure for humans. It is now generally superseded by the reference dose.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

mar·gin of safe·ty

the range between the minimal therapeutic dose and the minimal toxic dose of a drug.
Farlex Partner Medical Dictionary © Farlex 2012

mar·gin of safe·ty

(mahr'jin sāf'tē)
The area between the minimal therapeutic dose and the minimal toxic dose of a drug.
Synonym(s): safety margin.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

mar·gin of safe·ty

(mahr'jin sāf'tē)
The gap (i.e., range) between the minimal therapeutic dose of a drug and its minimal toxic dose.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
The factor of safety calculated using the nonlinear shear strength of a natural expansive soil cutting slope without wet-dry cycles is 2.32, and the maximum vertical sliding depth is 4.38 m.
Slope B Slope angle [beta] 1:3 1:2 1:1 2:1 [k.sub.c] 0.131 0.112 0.076 0.02 [u.sub.x] (cm) Imperial Valley-06 21.84 31.44 44.89 218.88 Kobe 48.51 75.41 118.81 499.22 Parkfield-02 55.29 76.15 120.45 581.24 Figure 6: Validation of the results of the static factor of safety (slope A).
In term of deterministic analysis, a slope is likely to fail if the factor of safety is equal or less than one (FS [less than or equal to] 1).
The percentage improvement in cover stability ([P.sub.R]) defined herein as the ratio of long-term factor of safety of geosynthetic-reinforced cover slope to that of the unreinforced structure may be as high as 150% for the range of seismic events covered in hazard mitigation programs.
(17.)See, e.g., Sieracki, 149 F.2d at 99 (factor of safety of 1.25 insufficient); Trozma v.
Figure 12 shows the factor of safety changes over time when the slope angle was varied with the same density of sand.
As a result, liquefaction potential is evaluated only by the factor of safety. In this paper, probabilistic concepts are used in determination of liquefaction potential.
For purposes of analysis, Rudakov and Pursell decided that 500 million cycles--a dozen or more years worth of heartbeats--was an infinite life in determining the factor of safety against fatigue failure.
Despite the progress of simulation techniques, the use of the factor of safety (FOS) is still the most commonly adopted method in slope stability analysis.