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The d-isomer component of the vitamin B2 complex occurring in or required by most organisms and inactivated by avidin; participates in biologic carboxylations. It is a small molecule with a high affinity for avidin that can be readily coupled to a previously labeled antibody to allow visualization by enzymatic or histochemical means.
See also: avidin.
See also: avidin.
biotin/bio·tin/ (bi´o-tin) a member of the vitamin B complex; it is a cofactor for several enzymes, plays a role in fatty acid and amino acid metabolism, and is used in vitro in some biochemical assays.
A vitamin, C10H16N2O3S, that is a component of the vitamin B complex and is a cofactor in many enzyme systems. It is found in large quantities in liver, egg yolk, milk, and yeast and is used in many biotechnology applications.
Etymology: Gk, bios, life
a colorless, crystalline, water-soluble B complex vitamin that acts as a coenzyme in fatty acid production and in the oxidation of fatty acids and carbohydrates. It also aids in the use of protein, folic acid, pantothenic acid, and vitamin B12. Rich sources are egg yolk, beef liver, kidney, unpolished rice, brewer's yeast, peanuts, cauliflower, and mushrooms. Formerly called vitamin H. See also avidin.
biotinA water-soluble B vitamin.
Biotin is the d-isomer of vitamin-B2 complex, which is a prosthetic group for carboxylase enzymes and important in fatty acid biosynthesis and catabolism. It is present in and essential for most animals, as it participates in carboxylation; daily requirements are in the mg range; biotin deficiency is rare.
Biotin is widely used as a covalent label for macromolecules which are detected by high-affinity binding of labelled avidin or streptavidin.
Biotin can be incorporated into dUTP and used as a non-radioactive label for a DNA probe. It is used to label nucleic acids and proteins that may be subsequently detected by avidin or streptavidin linked to a fluorescent or enzymatic reporter molecule.
The d-isomer component of the vitamin B2 complex occurring in or required by most organisms and inactivated by avidin; participates in biologic carboxylations.
biotinA water-soluble B vitamin concerned in the metabolism of fats and carbohydrates. Deficiency causes DERMATITIS, muscle pain, loss of appetite and ANAEMIA.
biotina water-soluble vitamin of the B-COMPLEX present in many foods, including yeast, liver and fresh vegetables. Biotin acts as a COENZYME in amino acid and lipid METABOLISM. A deficiency (rare in humans) of biotin causes dermatitis and intestinal problems.
n a B vitamin synthesized by bacteria within the gut; acts as a cofactor with enzymes; thought useful in the treatment of diabetes and brittle nails. Supplementation is not usually necessary except with pregnancy, inflammatory bowel disease, or antibiotic or anticon-vulsant medications. No known precautions.
The d-isomer component of the vitamin B2 complex occurring in or required by most organisms and inactivated by avidin.
See also: avidin
See also: avidin
a member of the vitamin B complex, required by or occurring in all forms of life tested; prosthetic group of carboxylase enzymes. Called also vitamin H, coenzyme R.
biotin nutritional deficiency
natural animal diets are unlikely to be deficient in biotin. Experimental deficiency causes paralysis in calves. In pigs the syndrome includes alopecia, dermatitis and cracking of the hooves. The vitamin may be an important factor in the maintenance of pig hoof health. See also porcine footrot. Deficiency in dogs and cats is associated with dry scurfy skin, alopecia, especially around the eyes, and a papulocrustaceous dermatitis. It can be caused by a diet with very high levels of uncooked egg whites. See also avidin.