Qualitative variables like gender, factor VIII inhibitor
level was reported as frequency and percentages.
Most of the time the disorder can be attributed to a factor VIII inhibitor
(acquired haemophilia A-AHA) (5), but inhibition of other factors is also a possibility.
The Bethesda assay (factor VIII inhibitor
screening) was negative for an inhibitor.
Dai et al., "Characterization of an acquired factor VIII inhibitor
and plasmapheresis therapy in a patient with bullous pemphigoid," Thrombosis and Haemostasis, vol.
These agents (factor VIII inhibitor
bypassing agent or recombinant factor VIIa), in spite of the fact that they do not contain factor VIII are effective in these patients because they bypass the factor VIII deficiency by increasing the activity of other coagulation factors.
He was discharged five days later in good condition, with a PTT of 49 s, factor VIII level of 0.09 IU/mL, factor VIII inhibitor
level of 2.34 Bethesda Units/mL, and creatinine of 105 mmol/L.
Life-threatening sublingual hematoma in a severely hemophilic patient with factor VIII inhibitor
. J Oral Maxillofac Surg.
Her factor VIII level was 2.3% and her factor VIII inhibitor
level was 25 Bethesda units (measure of the level of inhibitor to coagulation factor VIII; equal to the amount of inhibitor in patient plasma that will inactivate 50% of factor VIII in an equal volume of normal plasma after a 2-h incubation period.
The advantages of giving as little factor VIII as possible would be avoiding the risk of developing factor VIII inhibitor
antibodies or emergent infection and minimising the risk of acute thrombosis (including stent thrombosis) due to excessive factor VIII or coronary vasospasm after DDAVP.
Fulcher, "Localization of epitopes for human factor VIII inhibitor
antibodies by immunoblotting and antibody neutralization," Blood, vol.
Factor VIII inhibitor
formation in case 1 occurred 6 months after giving birth; underlying disorders were not identified in cases 2 or 3.