Acceleron is developing ACE-083 for diseases such as facioscapulohumeral
dystrophy and Charcot-Marie-Tooth disease, in which improved muscle strength in target muscles may provide a clinical benefit and enhance quality of life.
Signficance of Beevor's sign in facioscapulohumeral
dystrophy and other neuromuscular diseases.
dystrophy (FSHD) is an autosomal dominant disorder that is clinically defined as progressive asymmetric muscular weakness, typically of the face, scapular stabilizers, and proximal arm and leg .
The paper entitled "A Human Pluripotent Stem Cell Model of Facioscapulohumeral
Muscular Dystrophy-Affected Skeletal Muscles" is available here: http://goo.
Genetic counselling in facioscapulohumeral
It has been demonstrated that diagnosis of Facioscapulohumeral
muscular dystrophy (FSHD) could be distinguished from Duchenne muscular dystrophy based on the level of miRNAs-381 and miRNAs-382 expressions in FSHD patients (175).
The disease, facioscapulohumeral
muscular dystrophy, known as FSHD, is one of the most common forms of muscular dystrophy.
Brachial plexopathy following thoracoscapular fusion in facioscapulohumeral
There are several forms of muscular dystrophy (MD) that affect children including Duchenne, facioscapulohumeral
, limb-girdle, and myotonic muscular dystrophy.
Dystrophy Physical Therapy 2008 88: 105-113 http://www.
Five common types of MD are Becker MD (BMD), Duchenne MD (DMD), Limb-Girdle MD (LGMD), Facioscapulohumeral
MD (FSHD), and Myotonic MD (MMD) (Chert, 2001; Livneh & Antonak, 1997).
muscular dystrophy affects slightly more men than women and those with milder forms may not have symptoms until middle age.