N-terminal (JH 7) of Jak molecule has a receptor binding site while C-terminal (JH 1) is responsible for catalytic activity.1,3 These regions have four functional domains, which includes a FERM (band 4.1, ezrin
, radixin, moesin), an SH2 (Src homology 2) like domain, a tyrosine kinase and kinase-like pseudokinase domain.4,6-8
(22.) Williams P, Lopez H, Britt D, Chan C, Ezrin
A, Hottendorf R.
From the new album the evening opener Down On Me and the McCartney-like On My Own bounced along as did the Latin-inspired Honey Party with her audience contributing in the choruses, but my standout song and performance was her version of All My Heroes, beautifully sad and melancholic with Peyroux plucking her ukulele and some soulful piano by Andy Ezrin
CD74 is the most common fusion partner; however, at least 12 fusion variants have been identified with other partners, including tropomyosin 3 (TPM3), solute carrier family 34 member 2 (SLC34-A2), ezrin
(EZR), syndecan 4 (SDC4), leucine rich repeats and immunoglobulin-like domains 3 (LRIG3), KDEL endoplasmic reticulum protein retention receptor 2 (KDELR2), golgi-associated PDZ and coiled-coil motif containing (GOPC), and coiled-coil domain containing 6 (CCDC6).
Merlin is a member of the band 4.1-superfamily of proteins and has some sequence homology with the Ezrin
, radixin, and moesin (ERM) family.
Merlin protein is part of 4.1 protein family, with homologies with other proteins, such as ezrin
, radixin, and moesin .
In TCR stimulation process, LCK can activate VAV GTPase to control the status of ezrin
and moesin cytoskeletal protein phosphorylation, which regulates a series of protein translocation events [31, 32].
Duan et al., "Berberine inhibits metastasis of nasopharyngeal carcinoma 5-8F cells by targeting rho kinase-mediated Ezrin
phosphorylation at threonine 567," Journal of Biological Chemistry, vol.
Feakins et al., "Organotypic culture model of pancreatic cancer demonstrates that stromal cells modulate E-cadherin, ^-catenin, and ezrin
expression in tumor cells," The American Journal of Pathology, vol.
, and protein kinase A form a multiprotein complex which tethers CFTR on the apical plasma membrane of airway epithelial cells and guarantees its correct functioning as a chloride channel .
, a membrane-cytoskeletal linking protein, mediates the connection of the membrane to cytoskeleton.