extrinsic coagulation pathway

ex·trin·sic co·a·gu·la·tion path·way

(eks-trin'zik kō-ag'yŭ-lā'shŭn path'wā)
A part of the coagulation pathway that is activated by contact of factor VII in the blood with tissue factor (TF), an integral membrane protein of extravascular plasma membranes. The integrity of this pathway can be tested by measuring the prothrombin time (PT).
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References in periodicals archive ?
Additionally, adding HES to this fluid severely increased the negative impact on the extrinsic coagulation pathway by increasing hemodilution.
3% HS with 7% vol hemodilution has no significant effect on intrinsic and extrinsic coagulation pathways and impairs fibrinogen--fibrin interaction less than 20% mannitol with 7% vol hemodilution in vitro.
A Comparison of the Effects of 20% Mannitol and 3% NaCl on Coagulation Parameters In Vitro using ROTEM: A Prospective Randomized Crossover Study/%20 Mannitol ve %3 NaCL Solusyonlarinin Koagulasyon Parametereleri Uzerine Etkisinin In Vitro Olarak Karsilastirilmasi: Prospektif, Randomize Capraz Calisma
Exposure of the blood to tissue factor triggers the extrinsic coagulation pathway whose function is monitored by the prothrombin time (PT) through interaction of tissue factor with activated coagulation factor.
Exposure of the blood to tissue factor triggers the extrinsic coagulation pathway whose function is monitored by the PT through interaction of tissue factor with activated coagulation factor VII (FVII).
Study of effect of traffic air pollutants on blood coagulation parameters among Saudi traffic policemen in Eastern Province
sup][5] These factors could trigger the extrinsic coagulation pathway.
Polycythemia, Ablepsia, and Obesity Hypoventilation Syndrome: A Case Report
In addition, all patients were screened by several laboratory tests, including measurement of the complete blood count (CBC), including platelet count; prothrombin time (PT) to evaluate the extrinsic coagulation pathway (factor II, V, VII, and X activity), which were converted to calculate the International Normalized Ratio (INR) (7); and activated partial thromboplastin rime (aPTT) to evaluate the intrinsic coagulation pathway (factor VIII, IX, XI, and XII activity).
Ascertainment of PT and INR can detect disturbances of the extrinsic coagulation pathway caused by an intake of oral anticoagulants or secondary to liver disease.
Unidentified coagulation disorders in post-tonsillectomy hemorrhage
This fibrin clot forms via (1) the intrinsic coagulation pathway, when activated factor XII (FXIIa) binds to the exposed endothelial cells at the site of injury and (2) the extrinsic coagulation pathway, when small amounts of circulating FVIIa bind to tissue factor released from injured endothelial tissues.
A review of disseminated intravascular coagulation: presentation, laboratory diagnosis and treatment
The pathogenesis of acute disseminated intravascular coagulation is believed to involve the liberation of thromboplastins produced by the tumor cells, with resultant activation of the extrinsic coagulation pathway.
Gingival bleeding: initial presentation of prostatic cancer

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