extramammary Paget's disease


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extramammary Paget's disease

 A lesion similar to Paget's disease of breast, less often linked to underlying malignancy; the condition arises from skin adnexae, visceral malignancy or rarely, de novo, in scrotum, perineum, labia majora; cells are more often mucin-positive than in Paget's disease of breast
References in periodicals archive ?
Lee, "Depigmented genital extramammary Paget's disease: a possible histogenetic link to Toker's clear cells and clear cell papulosis," Journal of Cutaneous Pathology, vol.
Diffuse CK7, CAM5.2 and BerEP4 positivity in pagetoid squamous cell carcinoma in situ (pagetoid Bowen's disease) of the perianal region: A mimic of extramammary Paget's disease. Histopathology 2013;62:511-4.
Potential diagnostic utility of CDX-2 immunophenotyping in extramammary Paget's disease. Appl Immunohistochem Mol Morphol.
Although the vulva is the commonest site of extramammary Paget's disease, it only comprises 1-2% of vulvar malignancies [73].
Matsunaga, "Mammary and extramammary Paget's disease," Anais Brasileiros de Dermatologia, vol.
Rare consequence of HHD is squamous-cell carcinoma.[12] The differential diagnoses of Hailey-Hailey disease included fungal infection, intertrigo, psoriasis, extramammary Paget's disease, acanthosis nigricans, pemphigus vegetans and Darier's disease.
Extramammary Paget's disease of the penis with features of Bowen's disease.
Extramammary Paget's disease (EMPD) is a rare skin disease and amongst which the EMPD of the scrotum is the commonest.
Skin conditions with a similar appearance to lichen simplex chronicus include lichen planus, lichen sclerosus, psoriasis, mycosis fungoides, and extramammary Paget's disease. (1,2,4,5)
Actually, several reports revealed that the expression of MMP-9 on tumors was correlated with the progression or prognosis of several skin tumors such as malignant melanoma, squamous cell carcinoma, basal cell carcinoma, mycosis fungoides, extramammary Paget's disease, and angiosarcoma [7, 9, 141-9].
Extramammary Paget's disease (EMPD) is a rare neoplasm with only a limited number of reported cases in literature.
These include morpheaform BCC, squamous cell carcinoma, lentigo maligna of the face (associated with a recurrence rate of 10% to 20% following surgery alone (6)), and extramammary Paget's disease (recurrence rate of 40% after surgery alone (6)), In addition, topical imiquimod may be helpful for reducing the 50% rate of recurrence following surgical excision of keloids.