The ability of Hp to neutralize potential oxidation from the heme in Hb is especially important in DM, where there is increased free extracorpuscular
Hb and increased systemic oxidative stress due to hyperglycemia .
Reappraisal of the etiology of extracorpuscular
non-autoimmune acquired hemolyticanemia in 2657 hospitalized patients with non-neoplastic disease.
aplastic anemia, intracorpuscular and extracorpuscular
defects of RBC, collagen disorders etc.
It is the main cause of acquired extracorpuscular
haemolysis in children.
(3.) Reddy VB: Extracorpuscular
defects leading to increased erythrocyte destruction-nonimmune causes.