The ability of Hp to neutralize potential oxidation from the heme in Hb is especially important in DM, where there is increased free
extracorpuscular Hb and increased systemic oxidative stress due to hyperglycemia [2].
Reappraisal of the etiology of
extracorpuscular non-autoimmune acquired hemolyticanemia in 2657 hospitalized patients with non-neoplastic disease.
aplastic anemia, intracorpuscular and
extracorpuscular defects of RBC, collagen disorders etc.
It is the main cause of acquired
extracorpuscular haemolysis in children.
(3.) Reddy VB:
Extracorpuscular defects leading to increased erythrocyte destruction-nonimmune causes.