Witte, "Intrinsic optical signals in rat neocortical slices measured with near-infrared dark-field microscopy reveal changes in
extracellular space," Journal of Neuroscience, vol.
A release of S1P into the
extracellular space might demonstrate another route of disposing S1P.
It will be of particular interest to evaluate changes in the nerve fiber layer, ganglion cell density, photoreceptor abnormalities, retinal thickness, and the quantification of the
extracellular space of the retina.
Exocytosis is an evolutionary trait of eukaryotic cells that leads in a given secretory cell to a release of chemical content by a fast mechanism into the
extracellular space and thus to communication with neighboring cells.
The coincidence of measured sulfate space and our physical determination of extracellular fluid indicated an
extracellular space of about 40% in C.
This loss of body weight appears to result largely from physiologic contraction of the
extracellular space after birth [4,5].
In addition, Nad-producing enzymes, Such as nampt, Moonlight in the
extracellular space, Exerting strongly pro-oncogenic, Autocrine and paracrine effects.
Under necrotic condition, contents of the cytosol are dispersed into the
extracellular space due to cellular distress or damage [16].
Beginning with the work of Geoffrey Burnstock in the 1970s, a role for adenosine triphosphateATP (which is a ubiquitous energy source) and its metabolites (e.g., adenosine diphosphate [ADP] and adenosine) in the
extracellular space acting on cell surface receptors has now been established.
They can be found next to microfibrils or collagen fibrils, but also free in the
extracellular space [ILLUSTRATION FOR FIGURE 19 OMITTED].
Objective: Aggregates of proteins such as amyloid-beta and alpha-synuclein circulate the
extracellular space of the brain (ecs) and are thought to be key players in the development of neurodegenerative diseases.
For example, they take up GABA from the
extracellular space (1) through the action of a sodium-de-pendent transporter (2), and they possess functional [GABA.sub.A] receptors that activate membrane chloride channels (3).
