extracellular matrix


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extracellular matrix

the aggregate of proteins secreted by cells.

extracellular matrix

Non-living material secreted by cells that fills spaces between the cells in a tissue, protecting them and helping to hold them together. The extracellular matrix may be semifluid or rigidly solid and hard as in bone. It is composed mainly of protein and includes collagens, elastin, reticulin, glycoproteins, proteoglycans, fibronectin, laminins and osteopontin.

extracellular matrix (ECM)

see MATRIX.
References in periodicals archive ?
And altering the way breast cancer cells interact with some proteins in the extracellular matrix coaxes cancer cells to behave like normal cells, her team showed in 1997.
Immunoelectronmicroscopic localization of extracellular matrix components produced by bovine corneal endothelial cells in vitro.
The lack of vinculin, a member of the adherent junction proteins, would suggest that signal transduction between the cell and extracellular matrix is not intact in the affected bowel in HD.
Slime molds develop through the movement of interconnected cells within a carbohydrate extracellular matrix. Animals are infolded balls, coated by sheets of cells, containing a collagen-proteoglycan extracellular matrix, through which other cells move.
The extracellular matrix of the dermis: flexible structures with dynamic functions.
Dynamic reciprocity: how do extracellular matrix and hormones direct gene expression?
Importantly, these findings could have broader relevance to other biological systems where living cells are enmeshed within and surrounded by an extracellular matrix, such as in biofilms, which are associated with many human infectious diseases.
That is, once the heart is damaged, extracellular matrix that connects cardiomyocytes will be degenerated by increased MMP for the adaptation of cardiomyocyte enlargement and fibroblast invasion.
On the other hand, the depth of deposition into the extracellular matrix was positively associated with the duration of exposure.
A new discovery published in the journal Immunity confirms that interactions between the extracellular matrix (ECM), which plays an important role in modifying cell behavior, and integrins, cell surface receptors that are responsible for interaction of cells within the ECM, can regulate gene expression.
The company's expertise in extracellular matrix biology, coupled with its substantial intellectual property position, allows FibroGen Europe to assume a leadership position in the recombinant collagen and gelatin marketplaces.

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