excitotoxin


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excitotoxin

(ĭk-sī′tə-tŏk′sĭn)
n.
Any of a group of neurologically active compounds, including glutamate and aspartame, that in high concentrations have detrimental excitatory effects on the central nervous system and may cause injury to nerve cells.

ex·ci′to·tox′ic (ĭk-sī′tə-tŏk′sĭk) adj.

excitotoxin

(ĕk-sī″tō-tŏks′ĭn)
A neurotransmitter (e.g., glutamate or aspartate) that can cause brain cell injury or death if its action is unabated. Brain damage is mediated by excitotoxins during prolonged seizure activity and stroke.
References in periodicals archive ?
Thus, RTX is an excitotoxin that stimulates TRPV1 at low doses and desensitizes it at high doses.
(16) Lithium's ability to stimulate neural stem cell production may prove to be of significant benefit in individuals recovering from spinal cord injury and neurological injuries caused by severe trauma (TBI, traumatic brain injury), dietary and environmental excitotoxins (mercury, aspartame, monosodium glutamate), and substance abuse.
Shaw, "Excitatory amino acid neurotransmission, excitotoxicity and excitotoxins," Current Opinion in Neurology and Neurosurgery, vol.
Double dissociations of the effects of amygdala and insular cortex lesions on conditioned taste aversion, passive avoidance, and neophobia in the rat using the excitotoxin ibotenic acid.
Behavioral disinhibition following basal forebrain excitotoxin lesions: Alcohol consumption, defensive aggression, impulsivity and serotonin levels.
Domoic Acid (DA), a potent excitotoxin produces hippocampal damage and functional lesions as seen in temporal lobe epilepsy.
But aspartame acts like an excitotoxin, and excitotoxins are dangerous.
MSG is an excitotoxin that works by overstimulating its nerve target.
Gahring, "Inflammatory cytokines IL-1[alpha], IL-1[beta], IL-6, and TNF-[alpha] impart neuroprotection to an excitotoxin through distinct pathways," Journal of Immunology, vol.
Increased production of the neuromodulator quinolinic acid, an excitotoxin and N-methyl-D aspartate (NMDA) agonist, has been demonstrated in the CSF of patients with neurologic Lyme disease [143].
Increased lipid peroxidation during kindling is independent of iron salts and excitotoxin. These results indicate that during kindling there was excessive oxidative stress pertaining as a consequence glutathione levels were depleted while combating oxidative stress (Schulz et al.
Because APM is an excitotoxin, it stimulates the brain to destruction.