Possessing the property of exciting and then poisoning cells or tissues; examples include nerve injury and death produced by glutamate.
[excite + G. toxikon, poison]
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References in periodicals archive ?
CREB and NF-kappaB transcription factors regulate sensitivity to excitotoxic and oxidative stress induced neuronal cell death.
Chlorogenic acid is now known to protect brain cells from excitotoxic death by preventing the influx of calcium.
Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults.
Excitotoxic lesion of the hippocampus of Wistar rats disrupts the circadian control of the latent inhibition of taste aversion learning.
During the first 10 days succeeding a TBI, known as the acute phase, the following excitotoxic events occur: terminal membrane depolarization along with excessive release of excitatory neurotransmitters (i.
In a recent experimental study of a neonatal animal model of excitotoxic brain injury, [16] showed that G-CSF protects against N-methyl-D-aspartate receptor-mediated developmental excitotoxic brain damage.
The 3NPA mimics a downstream process of cell death seen in selective excitotoxic striatal pathology in the Huntington's disease (HD) brain, namely mitochondrial impairment, where it inhibits the mitochondrial enzyme succinate dehydrogenase [10].
Mitochondrial ATP-Mg/Pi earner SCaMC-3/Slc25a23 counteracts PARP-1-dependent fall in mitochondrial ATP caused by excitotoxic insults in neurons.
It has been reported that EAPL has neuroprotective effects against ischemia/reperfusion (I/R) damage, excitotoxic injury and hypoxia-reoxygen injury due to improving the redox imbalance and inhibiting apoptosis (Sun et al.
The effects of excitotoxic lesions of the nucleus accumbens core or shell regions on intravenous heroin self-administration in rats.
The increase in mI in the thalamus could be ascribed to the regulation of osmolalityvia SMIT, which prevents excitotoxic damage to neuronal cells.