excitatory synapse


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.

excitatory synapse

A synapse which, on activation, increases the likelihood of an action potential on the post-synaptic neuron or increases the frequency of firing of the post-synaptic neuron.
References in periodicals archive ?
These structural changes occur rapidly (within 20-30 min) and locally (within a radius of few hundreds of nanometers from excitatory synapses).
It is clear that potential in both of the graphs is rising from zero to a positive value which represents that AMPA is only responsible for excitatory synapse. Here simulations are run for two different frequency ranges, 10Hz and 40Hz.
For the purpose of this work, only excitatory synapses are used since inhibitory neurons and glial cells can be incorporated into the main framework for fine regulation at various neuronal orders.
Chung et al., "NGL family PSD-95-interacting adhesion molecules regulate excitatory synapse formation," Nature Neuroscience, vol.
Moreover, the authors proved that oxytocin exposure of cultured mouse hippocampal glutamatergic neurons caused altered neuronal dendrite complexity and altered numbers of excitatory synapses. Another study found a decreased ratio of GABAergic versus total presynapses in hippocampal neurons cultured from oxytocin receptor knockout mice [67].
Hashimoto et al., "Oligomeric amyloid [beta] associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques," Proceedings of the National Academy of Sciences of the United States of America, vol.
TSP1 can bind postsynaptic neuroligins, increasing the speed of excitatory synapse formation at early stages in cultured rat hippocampal neurons, although not the final density of the synapses formed in mature neurons [101].
Cho et al., "Cerebellar Shank2 regulates excitatory synapse density, motor coordination, and specific repetitive and anxiety-like behaviors," Journal of Neuroscience, vol.
Furthermore, FMRP is essential for correct excitatory synapse elimination through the proteasomal degradation of PSD-95, and thus the defective degradation of PSD-95 might explain the excessive number of dendritic spines observed in patients with FXS [170].
Modulation of Glutamatergic Excitatory Synapse by P2X Receptors
Serial EM analyses have revealed that stimulation leads to a significant increase of the perimeter of excitatory synapse covered by PAPs, particularly at the axon-spine interface [41].