[sup] Cerebral damage induced by oxidative stress during DHCA attracts lots of attention, and excitatory amino acids
were observed to increase significantly after DHCA.
(9) reported that Mephenesin might be an antagonist of excitatory amino acids
and might have NMDA-blocking activity and proposed that the NMDA-blocking activity of Mephenesin might be relevant to its muscle relaxing activity.
Grillner, "Excitatory amino acids
and synaptic transmission: the evidence for a physiological function," Trends in Pharmacological Sciences, vol.
In CSF high performance liquid chromatography (HPLC) was performed to detect the levels of free amino acids including the excitatory amino acids
: aspartate (Asp) and glutamate (Glu), as well as the inhibitory amino acids: glycine (Gly) and y-aminobutyric acid (GABA).
Glutamate and the other excitatory amino acids
have at least four different types of receptors.
Brain ischemia is profoundly debilitating, inducing the release of excitatory amino acids
with subsequent receptor activation leading to calcium influx, metabolic and electrophysiological dysfunction and oxidative stress (including lipid peroxidation).
(3) Although the precise cause of these neuromuscular abnormalities has not been elucidated, one possible explanation is that they may be the result of neuronal injury mediated by excitatory amino acids
. (1) For example, Stevens4 suggested that abnormal sprouting and reinnervation of neurons in schizophrenia might be caused by such injury.
The excitatory amino acids
(EAAs), L-glutamate and aspartate, are considered the major endogenous neuroactive substances involved in excitatory neurotransmission.
Control of prolactin secretion by excitatory amino acids
. Endocrine 28(3):303-308.
Ischemia of intact dorsal root ganglia (DRG) in situ leads to massive neuron death due to ischemia-triggered secondary events, such as massive release of excitatory amino acids
from the neurons, their excessive accumulation and activation of neuron NMDA and other receptors, acidification, and loss of calcium homeostasis.
An analysis of excitatory amino acids
, nitric oxide and prostaglandin EZ in the cerebrospinal fluid of pregnant women: the effect on labor pain.
Excitatory amino acids
as a final common pathway for neurologic disorders.