excitatory amino acids

excitatory amino acids

[eksī′tətôr′ē]
one of a group of amino acids that affect the central nervous system by acting as neurotransmitters and in some cases as neurotoxins. Examples include glutamate and aspartate, which cause depolarization but may also trigger the death of neurons. Some excitatory amino acids are produced by plants and fungi and may be responsible for hypoxic or hypoglycemic brain damage.

excitatory amino acids

Aspartic acid and glutamic acid-amino acids that act on voltage-gated ion channels in the plasma membranes of cells of the nervous system to cause them to fire.
References in periodicals archive ?
sup][27] Cerebral damage induced by oxidative stress during DHCA attracts lots of attention, and excitatory amino acids were observed to increase significantly after DHCA.
9) reported that Mephenesin might be an antagonist of excitatory amino acids and might have NMDA-blocking activity and proposed that the NMDA-blocking activity of Mephenesin might be relevant to its muscle relaxing activity.
Glutamate and the other excitatory amino acids have at least four different types of receptors.
Brain ischemia is profoundly debilitating, inducing the release of excitatory amino acids with subsequent receptor activation leading to calcium influx, metabolic and electrophysiological dysfunction and oxidative stress (including lipid peroxidation).
3) Although the precise cause of these neuromuscular abnormalities has not been elucidated, one possible explanation is that they may be the result of neuronal injury mediated by excitatory amino acids.
The excitatory amino acids (EAAs), L-glutamate and aspartate, are considered the major endogenous neuroactive substances involved in excitatory neurotransmission.
Ischemia of intact dorsal root ganglia (DRG) in situ leads to massive neuron death due to ischemia-triggered secondary events, such as massive release of excitatory amino acids from the neurons, their excessive accumulation and activation of neuron NMDA and other receptors, acidification, and loss of calcium homeostasis.
An analysis of excitatory amino acids, nitric oxide and prostaglandin EZ in the cerebrospinal fluid of pregnant women: the effect on labor pain.
NPS Allelix Corporation (Mississauga, Canada) has patented mediation of neurotransmission by excitatory amino acids (EAAs) such as glutamate via membrane-bound surface receptors.
Cerebrospinal fluid (CSF) excitatory amino acids and cytokines were analyzed.

Full browser ?